(Rx) - indicates only available by prescription
To comply with Canadian International Pharmacy Association regulations you are permitted to order a 3 month or 100 day supply based on your personal prescription. read moreAs the amount of medicine constituting a day supply depends on your doctors directions for use, different patients are permitted to order different quantities. Placing an order for more than a 100 day supply may delay your order as we will need to contact you. Call 1-888-791-3784 for assistance if your 100 day rule compliant desired quantity is not shown.
ELIQUIS contains the active substance apixaban and belongs to a group of medicines called
anticoagulants. This medicine helps to prevent blood clots from forming by blocking Factor Xa, which
is an important component of blood clotting.
After an operation to the hip or knee you may be at a higher risk of developing blood clots in your leg
veins. This can cause the legs to swell, with or without pain. If a blood clot travels from your leg to
your lungs, it can block blood flow causing breathlessness, with or without chest pain. This condition
(pulmonary embolism) can be life-threatening and requires immediate medical attention.
ELIQUIS is specifically used in adults to help prevent blood clots from forming after hip or knee
Always take ELIQUIS exactly as your doctor has told you. You should check with your doctor or
pharmacist if you are not sure.
The usual dose is one tablet twice a day, for example, one in the morning and one in the evening.
Try to take the tablets at the same times every day to help you to remember to take them.
You should take the first tablet 12 to 24 hours after your operation.
Swallow the tablet with a drink of water.
You should take one tablet twice a day, every day, for as long as your doctor tells you to take this
Tell your doctor before you take this medicine if you have any of the following:
- an increased risk of bleeding, such as:
? bleeding disorders, including conditions resulting in reduced platelet activity
? an active or a recent ulcer of your stomach or bowel
? infection of the heart (bacterial endocarditis)
? recent bleeding in your brain (haemorrhagic stroke)
? very high blood pressure, not controlled by medical treatment
? a recent operation on your brain, spinal column or eye
- a severe kidney disease or if you are on dialysis
- a liver problem or a history of liver problems
Your doctor will perform a test on your liver function before you take ELIQUIS and it will be used
with caution in patients with signs of altered liver function.
- had a tube (catheter) or an injection into your spinal column (for anaesthesia or pain reduction),
your doctor will tell you to take ELIQUIS 5 hours or more after catheter removal
Children and adolescents
ELIQUIS is not recommended in children and adolescents under 18 years of age.
Some medicines may increase the effects of ELIQUIS and some may decrease its effects. Your doctor
will decide, if you should be treated with ELIQUIS when taking these medicines and how closely you
should be monitored.
The following medicines may increase the effects of ELIQUIS and increase the chance for unwanted
- some medicines for fungal infections (ketoconazole, etc.)
- some antiviral medicines for HIV / AIDS (e.g. ritonavir)
- other medicines that are used to reduce blood clotting (e.g. enoxaparin, etc.)
- anti-inflammatory or pain medicines (e.g. aspirin or naproxen)
- medicines for high blood pressure or heart problems (e.g. diltiazem)
The following medicines may reduce the ability of ELIQUIS to help prevent blood clots from forming.
- medicines to prevent epilepsy or seizures (e.g. phenytoin, etc.)
- St John's Wort (a herbal supplement used for depression)
- medicines to treat tuberculosis or other infections (e.g. rifampicin)
Taking ELIQUIS with food and drink
ELIQUIS can be taken with or without food.
Like all medicines, ELIQUIS can cause side effects, although not everybody gets them.
ELIQUIS may cause bleedings which may potentially be life threatening. The bleedings may not be
obvious and could possibly lead to anaemia, (a low blood cell count which may cause tiredness or
Frequencies are defined as follows:
- very common: affects more than 1 user in 10
- common: affects 1 to 10 users in 100
- uncommon: affects 1 to 10 users in 1,000
- rare: affects 1 to 10 users in 10,000
- very rare: affects less than 1 user in 10,000
Common side effects
- Anaemia which may cause tiredness or paleness
- Bleeding including:
- blood in the urine (that stains the urine pink or red)
- bruising and swelling
- vaginal bleeding
- Nausea (feeling sick)
Uncommon side effects
- Reduced number of platelets in your blood (which can affect clotting)
- Bleeding including:
- bleeding occurring after your operation including bruising and swelling, blood or liquid
leaking from the surgical wound/incision (wound secretion)
- bleeding in your stomach, bowel or blood in the stools
- blood found in the urine on laboratory testing
- bleeding from your nose
- Low blood pressure which may make you feel faint or have a quickened heartbeat
- Blood tests may show:
- abnormal liver function
- an increase in some liver enzymes
- an increase in bilirubin, a breakdown product of red blood cells, which can cause yellowing
of the skin and eyes.
Rare side effects
- Allergic reactions (hypersensitivity) which may cause: swelling of the face, lips, mouth, tongue
and/or throat and difficulty breathing. Contact your doctor immediately if you experience any of
- into a muscle
- in your eyes
- from your gums and blood in your spit when coughing
- from your rectum
If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please
tell your doctor or pharmacist.