Duloxetine, commonly marketed as Cymbalta, is used in the treatment of generalized anxiety disorder (GAD). The medication works as a serotonin-norephinephrine reuptake inhibitor and the dosage can vary from 30 mg to 120 mg a day. Symptoms can be significantly improved with the use of this medication and there have been various scales of measurement used to view its effectiveness.
According to studies collected by the US National Library of Medicine and the National Institutes of Health, the improvement of GAD symptoms were noticed within the first few weeks of taking the medication.
Many people who are diagnosed with GAD also have other comorbid conditions such as peptic ulcer disease, irritable bowel syndrome, headaches and cardiovascular disease. The disease is twice as likely in occur in women, opposed to men.
When Duloxetine is introduced to the body, the reuptake of norepinephrine is inhibited. Additionally, the reuptake inhibition in the platelets is also greatly improved and this helps to reduce the amount of pain that the body feels.
Due to the half-life of Duloxetine, it is effective as a daily treatment. It will have the maximum effect on the inhibitors, though because of it being taken daily, it can have drug interactions between other enzymes and inducers. This means that doctors need to know the full medical history of a patient prior to prescribing Duloxetine (Cymbalta) for GAD.
The ratings used to show the effectiveness of Duloxetine for treating GAD include the Hamilton Anxiety Rating Scale and the Clinical Global Impressions Scale. A decrease in the HAMA score was seen across the board when Duloxetine was introduced into the body in comparison to the placebo.
More than 65 million Americans are affected by generalized anxiety disorder every year and it can have a negative impact on the way that they function in family and social situations as well as at work. With many studies being done on the effectiveness of Duloxetine, it has been shown that it can provide the help that a person needs.
If GAD is left untreated, according to Medical News Today, it can impact more aspects of a person’s life. The debilitating condition can be improved with medication. Cymbalta, as Duloxetine is commonly named in the market, is commonly prescribed to adults as a way to manage the depression as well as the pain because of its effect on serotonin levels and its ability to inhibit the uptake of norepinephrine. It is not a drug that is prescribed to everyone with GAD, however many patients have been able to use the drug and experience the benefits.