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(pak'' li tax' el)Paclitaxel injection must be given in a hospital or medical facility under the supervision of a doctor who is experienced in giving chemotherapy medications for cancer. Paclitaxel injection may cause a large decrease in the number of white blood cells (a type of blood cell that is needed to fight infection) in your blood. This increases the risk that you will develop a serious infection. You should not receive paclitaxel if you already have a low number of white blood cells. Your doctor will order laboratory tests before and during your treatment to check the number of white blood cells in your blood. Your doctor will delay or interrupt your treatment if the number of white blood cells is too low. Call your doctor immediately if you develop a temperature greater than 100.4 °F (38 °C); a sore throat; cough; chills; difficult, frequent, or painful urination; or other signs of infection during your treatment with paclitaxel injection. Paclitaxel injection is manufactured with additional ingredients to allow the medication to reach parts of the body where it is needed. One form of paclitaxel injection (Abraxane) is manufactured with human albumin, and the other form of paclitaxel injection (Onxol, Taxol) is manufactured with a solvent called polyoxyethylated castor oil. There are important differences between the two forms of paclitaxel, so these products should not be substituted for each other. If you are using the form of paclitaxel injection that is manufactured with polyoxyethylated castor oil, you may experience a serious or life-threatening allergic reaction. You will receive certain medications to help prevent an allergic reaction before you receive each dose of paclitaxel. Tell your doctor if you experience any of the following symptoms of an allergic reaction: rash; hives; itching; swelling of the eyes, face, throat, lips, tongue, hands, arms, feet, or ankles; difficulty breathing or swallowing; flushing; fast heartbeat; dizziness; or fainting. Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to paclitaxel injection. Talk to your doctor about the risks of receiving paclitaxel injection.
Before receiving paclitaxel injection,
- tell your doctor and pharmacist if you are allergic to paclitaxel, any other medications, human albumin, polyoxyethylated castor oil, or medications that contain polyoxyethylated castor oil such as cyclosporine injection (Sandimmune) and teniposide (Vumon). Ask your doctor or pharmacist if you do not know if a medication that you are allergic to contains human albumin or polyoxyethylated castor oil.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: amiodarone (Cordarone, Pacerone); certain antibiotics such as clarithromycin (Biaxin), erythromycin (E.E.S., E-Mycin), and telithromycin (Ketek); certain antifungals such as itraconazole (Sporanox) and ketoconazole (Nizoral); aripiprazole (Abilify);certain benzodiazepines such as alprazolam (Xanax), diazepam (Valium), midazolam, and triazolam (Halcion); buspirone (Buspar); certain calcium channel blockers such as amlodipine (Norvasc, in Azor, in Caduet, in Lotrel), diltiazem (Cardizem, Dilacor, Tiazac), nifedipine (Adalat, Procardia), nisoldipine (Sular), and verapamil (Calan, Tarka, Verelan); carbamazepine (Carbatrol, Equetro, Tegretol); other chemotherapy medications for cancer such as doxorubicin (Doxil); certain cholesterol-lowering medications (statins) such as atorvastatin (Lipitor), lovastatin (Mevacor), and simvastatin (Zocor); cimetidine (Tagamet); cisplatin (Platinol); cyclosporine (Gengraf, Neoral, Sandimmune); fluoxetine (Prozac, Safarem, in Symbyax); efavirenz (Sustiva, in Atripla); fluvoxamine; gemfibrozil (Lopid); imatinib (Gleevec); methadone (Dolophine); montelukast (Singulair); nefazodone; nevirapine (Viramune); phenytoin; pimozide (Orap); protease inhibitors used to treat human immunodeficiency virus (HIV) such as indinavir (Crixivan), ritonavir (Norvir, in Kaletra), nelfinavir (Viracept), and saquinavir (Invirase); quinidine; quinine (Qualaquin); rifampin (Rimactane, Rifadin, in Rifamate); sildenafil (Viagra); tacrolimus (Prograf); tamoxifen (Nolvadex); trazodone; and vincristine. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with paclitaxel, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
- tell your doctor if you have or have ever had liver or heart disease.
- tell your doctor if you are pregnant or plan to become pregnant, or if you plan to father a child. You or your partner should not become pregnant while you are receiving paclitaxel injection. You should use birth control to prevent pregnancy in yourself or your partner during your treatment with paclitaxel injection. Talk to your doctor about birth control methods that will work for you. If you or your partner become pregnant while receiving paclitaxel injection, call your doctor. Paclitaxel may harm the fetus.
- tell your doctor if you are breast-feeding.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are receiving paclitaxel injection.
- if you are using paclitaxel manufactured with polyoxyethylated castor oil, you should know that the medication contains alcohol. Do not drive a car or operate machinery until you know how this medication affects you. Talk to your doctor about the safe use of alcoholic beverages or medications that may affect your thinking or judgment during your treatment.
- talk to your doctor before you receive any vaccinations during your treatment with paclitaxel.
- you should know that paclitaxel may make it more difficult for your body to fight infection. Wash your hands often and avoid crowds and people who are sick during your treatment with paclitaxel.
- you should know that paclitaxel may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.
- pain, redness, swelling, or sores in the place where the medication was injected
- muscle or joint pain
- stomach pain
- sores in the mouth
- hair loss
- numbness, burning, or tingling in the hands or feet
- pale skin
- excessive tiredness
- unusual bruising or bleeding
- chest pain
- slow or irregular heartbeat
- hardening, darkening, or peeling of the skin in the area where the medication was injected
- blistering or peeling skin