Crixivan (Indinavir Sulfate)
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Indinavir Sulfate Information
(in din' a veer)
Before taking indinavir,
- tell your doctor and pharmacist if you are allergic to indinavir, any other medications, or any of the ingredients in indinavir capsules. Ask your pharmacist for a list of the ingredients.
- tell your doctor if you are taking any of the following medications: alfuzosin (Uroxatral); alprazolam (Xanax); amiodarone (Nexterone, Pacerone); cisapride (Propulsid) (not available in the U.S.); ergot-type medications such as dihydroergotamine (D.H.E. 45, Migranal), ergonovine (Ergotrate), ergotamine (Ergomar, in Cafergot, in Migergot), and methylergonovine (Methergine); lovastatin (Altoprev, Mevacor); lurasidone (Latuda); midazolam (Versed) by mouth; pimozide (Orap); sildenafil (only Revatio brand used for lung disease); simvastatin (Zocor, in Vytorin); or triazolam (Halcion). Your doctor will probably tell you not to take indinavir.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: bosentan (Tracleer); calcium-channel blockers such as amlodipine (Norvasc, in Amturnide, in Tekamlo), felodipine, nicardipine, and nifedipine (Adalat, Afeditab, Procardia); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, others); cholesterol-lowering medications (statins) such as atorvastatin (Lipitor, in Caduet) and rosuvastatin (Crestor); clarithromycin (Biaxin, in PrevPac); colchicine (Colcrys, Mitigare, in Col-Probenecid); dexamethasone; fluconazole (Diflucan); fluticasone (Flonase, Flovent, in Advair, in Dymista); itraconazole (Onmel, Sporanox); ketoconazole (Extina, Nizoral, Xolegel); other medications for HIV including atazanavir (Reyataz, in Evotaz), delavirdine (Rescriptor), efavirenz (Sustiva, in Atripla), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, in Kaletra, in Viekira Pak), and saquinavir (Invirase); medications for irregular heartbeat such as lidocaine (Glydo, Xylocaine) and quinidine (in Nuedexta); medications that suppress the immune system such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), and tacrolimus (Astagraf XL, Envarsus XR, Prograf); midazolam (Versed) by injection; certain phosphodiesterase inhibitors (PDE-5 inhibitors) used for erectile dysfunction such as sildenafil (Viagra), tadalafil (Adcirca, Cialis), and vardenafil (Levitra, in Staxyn); phenobarbital; phenytoin (Dilantin, Phenytek); quetiapine (Seroquel); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, in Rifamate, in Rifater); salmeterol (Serevent, in Advair); trazodone; and venlafaxine (Effexor). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with indinavir, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
- tell your doctor what herbal products you are taking, especially St. John's wort.
- if you are taking didanosine (Videx), take it at least one hour before or after indinavir.
- tell your doctor if you have or have ever had hemophilia (bleeding disorder in which the blood does not clot properly), diabetes, or kidney or liver disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking indinavir, call your doctor. You should not breastfeed if you are infected with HIV or if you are taking indinavir.
- you should know that your body fat may increase or move to different areas of your body such as your breasts, upper back, neck, chest, and stomach area. Loss of fat from the legs, arms, and face can also happen.
- you should know that you may experience hyperglycemia (increases in your blood sugar) while you are taking this medication, even if you do not already have diabetes. Tell your doctor immediately if you have any of the following symptoms while you are taking indinavir: extreme thirst, frequent urination, extreme hunger, blurred vision, or weakness. It is very important to call your doctor as soon as you have any of these symptoms, because high blood sugar that is not treated can cause a serious condition called ketoacidosis. Ketoacidosis may become life-threatening if it is not treated at an early stage. Symptoms of ketoacidosis include dry mouth, nausea and vomiting, shortness of breath, breath that smells fruity, and decreased consciousness.
- you should know that while you are taking medications to treat HIV infection, your immune system may get stronger and begin to fight other infections that were already in your body. This may cause you to develop symptoms of those infections. If you have new or worsening symptoms at any time during your treatment with indinavir, be sure to tell your doctor.
- change in sense of taste
- peeling or blistering skin
- back pain
- pain in the side of your body
- middle to lower stomach pain
- blood in urine
- muscle pain or weakness
- excessive tiredness
- unusual bleeding or bruising
- loss of appetite
- pain in the upper right part of your stomach
- flu-like symptoms
- dark yellow or brown urine
- yellowing of the skin or eyes
- shortness of breath
- fast heartbeat