Daklinza (Daclatasvir Dihydrochloride)
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Daclatasvir Dihydrochloride Information
(dak lat' as vir)
You may already be infected with hepatitis B (a virus that infects the liver and may cause severe liver damage) but not have any symptoms of the disease. In this case, taking daclatasvir may increase the risk that your infection will become more serious or life-threatening and you will develop symptoms. Tell your doctor if you have or ever had a hepatitis B virus infection. Your doctor will order a blood test to see if you have or have ever had hepatitis B infection. Your doctor will also monitor you for signs of hepatitis B infection during and for several months after your treatment. If necessary, your doctor may give you medication to treat this infection before and during your treatment with daclatasvir. If you experience any of the following symptoms during or after your treatment, call your doctor immediately: excessive tiredness, yellowing of the skin or eyes, loss of appetite, nausea or vomiting, pale stools, stomach pain, or dark urine. Keep all appointments with your doctor and the laboratory. Your doctor may order certain tests before, during, and after your treatment to check your body's response to daclatasvir. Talk to your doctor about the risk(s) of taking daclatasvir.-
Before taking daclatasvir,
- tell your doctor and pharmacist if you are allergic to daclatasvir, any other medications, or any of the ingredients in daclatasvir tablets. Ask your pharmacist for a list of the ingredients.
- tell your doctor if you are taking carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril), phenytoin (Dilantin, Phenytek), rifampin (Rifadin, Rimactane, in Rifamate, Rifater), or St. John's wort. Your doctor will probably tell you not to take daclatasvir if you are taking one or more of these medications.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, you are taking or plan to take. Be sure to mention any of the following: amiodarone (Nexterone, Pacerone); certain antibiotics such as clarithromycin (Biaxin, in Prevpac), nafcillin, rifapentine (Priftin), and telithromycin (Ketek); certain antifungals such as itraconazole (Onmel, Sporanox), ketoconazole, posaconazole (Noxafil), and voriconazole (Vfend); bosentan (Tracleer); buprenorphine and naloxone (Suboxone, Zubsolv); certain cholesterol-lowering medications (statins) such as atorvastatin (Lipitor, in Caduet), fluvastatin (Lescol), pitavastatin (Livalo), pravastatin (Pravachol), rosuvastatin (Crestor), and simvastatin (Flolipid, Zocor, in Vytorin); medication containing cobicistat (Stribild); dabigatran (Pradaxa); dexamethasone; digoxin (Lanoxin); efavirenz (Sustiva, in Atripla), etravirine (Intelence); certain HIV protease inhibitors such as atazanavir (Reyataz, in Evotaz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra, Technivie, Viekira Pak), and saquinavir (Invirase); modafinil (Provigil); nefazodone; nevirapine (Viramune); and warfarin (Coumadin, Jantoven). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with daclatasvir, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
- tell your doctor if you have had a liver transplant, any type of liver disease other than hepatitis C, or heart disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking daclatasvir, call your doctor.
- headache
- diarrhea
- near fainting or fainting
- dizziness or lightheadedness
- weakness or not feeling well
- shortness of breath
- chest pain
- memory problems
- confusion