Didronel (Etidronate Disodium)
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Etidronate Disodium Information
(e'' ti droe' nate)
- Swallow the tablets with a full glass (6 to 8 ounces [180 to 240 mL]) of plain water while you are sitting or standing.
- Sit or stand upright after taking etidronate.
- Do not eat, drink, or take any other medications (including vitamins or antacids) for 2 hours before and 2 hours after you take etidronate.
Before taking etidronate,
- tell your doctor and pharmacist if you are allergic to etidronate, any other medications, or any of the ingredients in etidronate tablets. Ask your pharmacist for a list of the ingredients.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: angiogenesis inhibitors such as bevacizumab (Avastin), everolimus (Afinitor, Zortress), pazopanib (Votrient), sorafenib (Nexavar), or sunitinib (Sutent); anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); cancer chemotherapy; and oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- if you are taking vitamin and mineral supplements such as iron, or if you are taking antacids containing calcium, magnesium, or aluminum (Maalox, Mylanta, Tums, others), take them 2 hours before or 2 hours after you take etidronate.
- tell your doctor if you have or have ever had problems with your esophagus such as an esophageal stricture (narrowing of the esophagus that causes swallowing difficulties) or achalasia (disorder which affects the ability of the esophagus to move food toward the stomach), or osteomalacia (softening of bones due to a lack of minerals). Your doctor may tell you not to take etidronate.
- tell your doctor if you are unable to sit or stand upright and if you have or have ever had anemia (condition in which the red blood cells do not bring enough oxygen to all the parts of the body); a low level of calcium in your blood; difficulty swallowing, heartburn, ulcers, or other stomach problems; cancer; enterocolitis (swelling in the intestines); any type of infection, especially in your mouth; problems with your mouth, teeth, or gums; any condition that stops your blood from clotting normally; or kidney disease. Your doctor may need to change the dose of your medications or monitor you carefully for side effects.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. Also tell your doctor if you plan to become pregnant at any time in the future because etidronate may remain in your body for years after you stop taking it. Call your doctor if you become pregnant during or after your treatment with etidronate.
- you should know that etidronate may cause osteonecrosis of the jaw (ONJ, a serious condition of the jaw bone), especially if you have dental surgery or treatment while you are taking the medication. A dentist should examine your teeth and perform any needed treatments, including cleaning or fixing ill-fitted dentures, before you start to take etidronate. Be sure to brush your teeth and clean your mouth properly while you are taking etidronate. Talk to your doctor before having any dental treatments while you are taking this medication.
- you should know that etidronate may cause severe bone, muscle, or joint pain. You may begin to feel this pain within days, months, or years after you first take etidronate. Although this type of pain may begin after you have taken etidronate for some time, it is important for you and your doctor to realize that it may be caused by etidronate. Call your doctor right away if you experience severe pain at any time during your treatment with etidronate. Your doctor may tell you to stop taking etidronate and your pain may go away after you stop taking the medication.
- new or worsening heartburn
- pain when swallowing
- chest pain
- swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
- difficulty swallowing
- blisters on the skin