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(oh lap' a rib)
Before taking olaparib,
- tell your doctor and pharmacist if you are allergic to olaparib, any other medications, or any of the ingredients in olaparib tablets or capsules. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antibiotics such as ciprofloxacin (Cipro), clarithromycin (Biaxin, in Prevpac), erythromycin (E.E.S., Erythrocin, others), nafcillin, and telithromycin (no longer available in U.S., Ketek); antifungals such as fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole (Extina, Nizoral, Xolegel), posaconazole (Noxafil), and voriconazole (Vfend); aprepitant (Emend); certain medications to treat seizures such as carbamazepine (Carbatrol, Epitol, Tegretol, Teril), and phenytoin (Dilantin, Phenytek); bosentan (Tracleer); crizotinib (Xalkori); diltiazem (Cardizem, Cartia, Tiazac, others); certain medications to treat hepatitis C such as boceprevir (no longer available in U.S., Victrelis) and telaprevir (no longer available in U.S., Incivek); certain medications to treat human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) such as amprenavir (no longer available in U.S., Agenerase), atazanavir (Reyataz, in Evotaz), darunavir (Prezista), efavirenz (Sustiva, in Atripla), etravirine (Intelence), fosamprenavir (Lexiva), indinavir (Crixivan), lopinavir/ritonavir (Kaletra), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), and saquinavir (Invirase); imatinib (Gleevec); modafinil (Provigil); nefazodone; other chemotherapy medications for cancer, rifampin (Rifadin, Rimactane, in Rifamate, in Rifater), and verapamil (Calan, Verelan, in Tarka). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor what herbal products you are taking, especially St. John's wort. You should not take St. John's wort while you are taking olaparib.
- tell your doctor if you have or have ever had have lung or breathing problems, or kidney or liver disease.
- tell your doctor if you are pregnant or plan to become pregnant. You may need to have a pregnancy test before starting treatment, You should not become pregnant while you are taking olaparib. You should use effective birth control to prevent pregnancy during your treatment with olaparib and for at least 6 months after your final dose. If you are a male and your partner can become pregnant, you should use effective birth control during your treatment with olaparib tablets and for 3 months after your final dose. Talk to your doctor about birth control methods that will work for you. If you become pregnant while taking olaparib, call your doctor immediately. Olaparib may harm the fetus.
- tell your doctor if you are breastfeeding. Do not breastfeed while you are taking olaparib and for 1 month after your final dose.
- you should know that you should not donate sperm while you are taking olaparib tablets and for 3 months after your treatment.
- decreased appetite
- muscle, joint, or back pain
- stomach pain or discomfort
- taste changes
- mouth pain or sores
- dry skin
- difficulty falling asleep or staying asleep
- sore throat, runny nose, or other cold symptoms
- pain urinating
- fever, cough, or wheezing
- shortness of breath
- extreme tiredness
- weight loss
- numbness, tingling, or burning sensation in the hands or feet
- unusual bruising or bleeding
- pale skin
- blood in urine or stool