Mavyret (Glecaprevir / Pibrentasvir)
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Glecaprevir / Pibrentasvir Information
(glek a' pre vir)(pi brent' as vir)You may already be infected with hepatitis B (a virus that infects the liver and may cause severe liver damage) but not have any symptoms of the disease. In this case, taking the combination of glecaprevir and pibrentasvir may increase the risk that your infection will become more serious or life-threatening and you will develop symptoms. Tell your doctor if you have or ever had a hepatitis B virus infection. Your doctor will order a blood test to see if you have or have ever had hepatitis B infection. Your doctor will also monitor you for signs of hepatitis B infection during and for several months after your treatment. If necessary, your doctor may give you medication to treat this infection before and during your treatment with the combination of glecaprevir and pibrentasvir. If you experience any of the following symptoms during or after your treatment, call your doctor immediately: excessive tiredness, yellowing of the skin or eyes, loss of appetite, nausea, vomiting, pale stools, pain in upper right side of the stomach area, or dark urine. Keep all appointments with your doctor and the laboratory. Your doctor may order certain tests before, during, and after your treatment to check your body's response to the combination of glecaprevir and pibrentasvir. Talk to your doctor about the risks of taking glecaprevir and pibrentasvir.
Before taking glecaprevir and pibrentasvir,
- tell your doctor and pharmacist if you are allergic to glecaprevir, pibrentasvir, any other medications, or any of the ingredients in the glecaprevir and pibrentasvir tablets. Ask your pharmacist for a list of the ingredients.
- tell your doctor if you are taking atazanavir (Reyataz, in Evotaz) or rifampin (Rifadin, Rimactane, in Rifamate, in Rifater). Your doctor will probably tell you not to take glecaprevir and pibrentasvir if you are taking one of these medications.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol), cholesterol-lowering medications (statins) such as atorvastatin (Lipitor, in Caduet), fluvastatin (Lescol), lovastatin (Altoprev), pitavastatin (Livalo), pravastatin (Pravachol), rosuvastatin (Crestor), and simvastatin (Zocor, in Simcor, in Vytorin); cyclosporine (Gengraf, Neoral, Sandimmune); dabigatran (Pradaxa); digoxin (Lanoxin); ethinyl estradiol oral contraceptives such as certain ('birth control pills'), patches, hormonal vaginal rings, and other ethinyl estradiol products; certain hormone replacement therapies (HRT); and certain medications for human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) including darunavir (Prezista, in Prezcobix), efavirenz (Sustiva, in Atripla), lopinavir (in Kaletra), or ritonavir (Norvir, in Kaletra); and phenytoin (Dilantin, Phenytek). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor what herbal products you are taking, especially St. John's wort.
- tell your doctor if you have any type of liver disease other than hepatitis C. Your doctor may tell you not to take glecaprevir and pibrentasvir.
- tell your doctor if you have or have ever had human immunodeficiency virus (HIV) or diabetes, or if you have ever received a liver or kidney transplant.
- tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking glecaprevir and pibrentasvir, call your doctor.
- swelling of stomach area
- vomiting blood or material that looks like coffee grounds
- dark, black, or bloody stools