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(soe" ni deg' ib)For all patients: Sonidegib should not be taken by women who are pregnant or who may become pregnant. There is a high risk that sonidegib will cause loss of the pregnancy or will cause the baby to be born with birth defects (physical problems that are present at birth). Do not donate blood or blood products while you are taking sonidegib and for at least 20 months after your treatment. Talk to your doctor about the risks of taking sonidegib. For female patients: If you can become pregnant, you will need to avoid becoming pregnant during your treatment with sonidegib. You must have a negative pregnancy test before the start of your treatment. You must use acceptable forms of birth control during your treatment and for at least 20 months after your treatment is completed. Your doctor will tell you which forms of birth control are acceptable. If you think you are pregnant, miss a menstrual period, or have sex without using birth control while taking sonidegib or within 20 months after your treatment, call your doctor immediately. For male patients: You must use a condom, even if you have had a vasectomy (surgery to prevent sperm from leaving your body and causing pregnancy), every time you have sexual contact with a female who is pregnant or able to become pregnant while you are taking sonidegib, and for at least 8 months after your treatment. Tell your doctor immediately if you have had unprotected sex with a woman who can become pregnant or if you think for any reason that your partner is pregnant. Do not donate semen while you are taking sonidegib or within 8 months after your treatment.