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(os pem' i feen)Taking ospemifene may increase the risk that you will develop endometrial cancer (cancer of the uterus [womb]). Tell your doctor if you have or have had cancer or if you have abnormal vaginal bleeding. Your doctor will probably tell you not to take ospemifene. If you have any unusual vaginal bleeding while you are taking ospemifene call your doctor immediately. Taking ospemifene also may increase the risk of stroke and blood clots. Tell your doctor if you tell your doctor if you smoke or have or have ever had a stroke, a blood clot in the legs and lungs, high blood pressure, high blood levels of cholesterol or fats, diabetes, heart disease, or lupus (a condition in which the body attacks its own tissues causing damage and swelling). Your doctor will probably tell you not to take ospemifene. Talk to your doctor every 3 to 6 months to decide if you should continue taking this medication. Talk to your doctor about the risks and benefits of taking this medication.
Before taking ospemifene,
- tell your doctor and pharmacist if you are allergic to ospemifene or any of the ingredients in ospemifene tablets. Ask your pharmacist for a list of the ingredients.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: antifungals such as itraconazole (Sporanox), fluconazole (Diflucan), ketoconazole (Nizoral);clarithromycin (Biaxin); estrogens such as (Premarin); estrogen agonists/antagonists such as tamoxifen (Nolvadex); medications for human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) such as indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), saquinavir (Fortovase, Invirase); nefazodone; or rifampin (Rifadin, Rimactane, in Rifamate). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor if you have or have ever had liver disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. Ospemifene may cause fetal harm. If you become pregnant while taking ospemifene, call your doctor immediately.
- if you are having surgery, including dental surgery, tell the doctor or dentist you are taking ospemifene.
- hot flashes or flushes
- vaginal discharge
- muscle spasms
- increased sweating
- changes in vision
- slow or difficult speech
- sudden severe headache
- pain in your chest or legs with or without shortness of breath, weakness, and fatigue