Trintellix (Vortioxetine)

They need to know if you have any of these conditions: -bipolar disorder or a family history of bipolar disorder -bleeding disorders -drink alcohol -glaucoma -liver disease -low levels of sodium in the blood -seizures -suicidal thoughts, plans, or attempt; a previous suicide attempt by you or a family member -take medicines that treat or prevent blood clots -an unusual or allergic reaction to vortioxetine, other medicines, foods, dyes, or preservatives -pregnant or trying to get pregnant -breast-feeding

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. You can take it with or without food. If it upsets your stomach, take it with food. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking this medicine suddenly except upon the advice of your doctor. Stopping this medicine too quickly may cause serious side effects or your condition may worsen. A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time. Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Do not take this medicine with any of the following medications: -linezolid -MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate -methylene blue (injected into a vein) This medicine may also interact with the following medications: -alcohol -aspirin and aspirin-like medicines -carbamazepine -certain medicines for depression, anxiety, or psychotic disturbances -certain medicines for migraine headache like almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan -diuretics -fentanyl -furazolidone -isoniazid -medicines that treat or prevent blood clots like warfarin, enoxaparin, and dalteparin -NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen -phenytoin -procarbazine -quinidine -rasagiline -rifampin -supplements like St. John's wort, kava kava, valerian -tramadol -tryptophan

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

Tell your doctor if your symptoms do not get better or if they get worse. Visit your doctor or health care professional for regular checks on your progress. Because it may take several weeks to see the full effects of this medicine, it is important to continue your treatment as prescribed by your doctor. Patients and their families should watch out for new or worsening thoughts of suicide or depression. Also watch out for sudden changes in feelings such as feeling anxious, agitated, panicky, irritable, hostile, aggressive, impulsive, severely restless, overly excited and hyperactive, or not being able to sleep. If this happens, especially at the beginning of treatment or after a change in dose, call your health care professional. You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks. Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.

Side effects that you should report to your doctor or health care professional as soon as possible: -allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue -anxious -black, tarry stools -changes in vision -confusion -elevated mood, decreased need for sleep, racing thoughts, impulsive behavior -eye pain -fast, irregular heartbeat -feeling faint or lightheaded, falls -feeling agitated, angry, or irritable -hallucination, loss of contact with reality -loss of balance or coordination -loss of memory -painful or prolonged erections -restlessness, pacing, inability to keep still -seizures -stiff muscles -suicidal thoughts or other mood changes -trouble sleeping -unusual bleeding or bruising -unusually weak or tired -vomiting Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome): -change in appetite or weight -change in sex drive or performance -constipation -dizziness -dry mouth -nausea

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Keep out of the reach of children. Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.