Viekira Pak (Ombitasvir / Paritaprevir / Ritonavir)
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Ombitasvir / Paritaprevir / Ritonavir Information
(om bit' as vir) (par'' I ta' pre vir) (ri toe' na vir) (da sa' bue vir)You may already be infected with hepatitis B (a virus that infects the liver and may cause severe liver damage) but do not have any symptoms of the disease. In this case, taking the combination of ombitasvir, paritaprevir, ritonavir, and dasabuvir may increase the risk that your infection will become more serious or life-threatening and you will develop symptoms. Tell your doctor if you have or ever had a hepatitis B virus infection. Your doctor will order a blood test to see if you have or have ever had hepatitis B infection. Your doctor will also monitor you for signs of hepatitis B infection during and for several months after your treatment. If necessary, your doctor may give you medication to treat this infection before and during your treatment with the combination of ombitasvir, paritaprevir, ritonavir, and dasabuvir. If you experience any of the following symptoms during or after your treatment, call your doctor immediately: excessive tiredness, yellowing of the skin or eyes, loss of appetite, nausea or vomiting, pale stools, stomach pain, or dark urine. Keep all appointments with your doctor and the laboratory. Your doctor may order certain tests before, during, and after your treatment to check your body's response to the combination of ombitasvir, paritaprevir, ritonavir, and dasabuvir. Talk to your doctor about the risk(s) of taking the combination of ombitasvir, paritaprevir, ritonavir, and dasabuvir.
Before taking ombitasvir, paritaprevir, ritonavir, and dasabuvir,
- tell your doctor and pharmacist if you are allergic to ombitasvir, paritaprevir, ritonavir, dasabuvir, any other medications, or any of the ingredients in ombitasvir, paritaprevir, ritonavir, and dasabuvir tablets. If you have had a serious or life-threatening reaction to ritonavir (rash, blistering or peeling of the skin), your doctor will probably tell not to take ombitasvir, paritaprevir, ritonavir, and dasabuvir. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
- tell your doctor if you are taking alfuzosin (Uroxatral); atorvastatin (Lipitor, in Caduet); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol); cisapride (Propulsid; no longer available in U.S.); dronedarone (Multaq); efavirenz (Sustiva, in Atripla); ergot-containing medicines such as dihydroergotamine mesylate (D.H.E. 45, Migranal), ergotamine (Ergomar, in Cafergot, in Migergot), and methylergonovine (Methergine); ethinyl estradiol oral contraceptives such as certain tablets ('birth control pills'), patches, hormonal vaginal rings, and other esthinyl estradiol products; everolimus (Afinitor, Zortress); gemfibrozil (Lopid); lovastatin (Altoprev); lurasidone (Latuda); midazolam (by mouth); phenobarbital; phenytoin (Dilantin, Phenytek); pimozide (Orap); ranolazine (Ranexa); rifampin (Rifadin, Rimactane, in Rifamate, in Rifater); sildenafil (Revatio) for treatment of pulmonary arterial hypertension; simvastatin (Zocor, in Vytorin); sirolimus (Rapamune); St. John's wort; tacrolimus (Astagraf XL, Envarsus XR, Prograf); or triazolam (Halcion). Also, tell your doctor if you are taking colchicine (Colcrys, Mitigare) and have liver or kidney disease. Your doctor will probably tell you not to take ombitasvir, paritaprevir, ritonavir, and dasabuvir if you are taking one or more of these medications.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: alprazolam (Xanax); acetaminophen and hydrocodone (Anexsia, Zyfrel); angiotensin receptor blocker (ARB) such as candesartan (Atacand, in Atacand HCT), losartan (Cozaar, in Hyzaar), and valsartan (Diovan, in Diovan HCT, Exforge); buprenorphine and naloxone (Suboxone, Zubsolv); calcium channel blockers such as amlodipine (Norvasc, in Caduet), diltiazem (Cardizem, Cartia), nifedipine (Adalat, Afeditab), and verapamil (Calan, Verelan); carisoprodol (Soma); cyclobenzaprine (Amrix); cyclosporine (Gengraf, Neoral, Sandimmune); diazepam (Valium); fluticasone (Flonase, Flovent, in Advair); furosemide (Lasix); medications for irregular heartbeat such as amiodarone (Nexterone, Pacerone), bepridil (no longer available in the U.S.), disopyramide (Norpace), flecainide, lidocaine (Xylocaine), mexiletine, propafenone (Rythmol), or quinidine (in Nuedexta); ketoconazole; metformin (Glucophage, Riomet); omeprazole (Prilosec); pravastatin (Pravachol); quetiapine (Seroquel); rilpivirine (Edurant; in Complera, in Odefsey); ritonavir (Norvir, in Kaletra) used in combination with other HIV protease inhibitors such as atazanavir (Reyataz), darunavir (Prezista), and lopinavir (in Kaletra); rosuvastatin (Crestor); salmeterol (Serevent, in Advair); and voriconazole (Vfend). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor if you have any type of liver disease other than hepatitis C. Your doctor may tell you not to take ombitasvir, paritaprevir, ritonavir, and dasabuvir.
- tell your doctor if you have ever had a liver transplant, anemia (a lower than normal number of red blood cells), or human immunodeficiency virus (HIV).
- tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking ombitasvir, paritaprevir, ritonavir, and dasabuvir, call your doctor.
- you should know that ombitasvir, paritaprevir, ritonavir, and dasabuvir may decrease the effectiveness of hormonal contraceptives (birth control pills, patches, rings, implants, injections, and intrauterine devices). Use another form of birth control while you are taking ombitasvir, paritaprevir, ritonavir, and dasabuvir and for 2 weeks after your final dose. Talk to your doctor about types of birth control that will work for you during and after your treatment with ombitasvir, paritaprevir, ritonavir, and dasabuvir.
- difficulty falling asleep or staying asleep
- reddening of the skin