Vosevi (Sofosbuvir / Velpatasvir / Voxilaprevir)
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Sofosbuvir / Velpatasvir / Voxilaprevir Information
(soe fos' bue vir) (vel pat' as vir) (vox" i la' pre vir)You may already be infected with hepatitis B (a virus that infects the liver and may cause severe liver damage), but not have any symptoms of the disease. In this case, taking the combination of sofosbuvir, velpatasvir, and voxilaprevir may increase the risk that your infection will become more serious or life-threatening and you will develop symptoms. Tell your doctor if you have or ever had a hepatitis B virus infection. Your doctor will order a blood test to see if you have or have ever had hepatitis B infection. Your doctor will also monitor you for signs of hepatitis B infection during and for several months after your treatment. If necessary, your doctor may give you medication to treat this infection before and during your treatment with the combination of sofosbuvir, velpatasvir, and voxilaprevir. If you experience any of the following symptoms during or after your treatment, call your doctor immediately: excessive tiredness, yellowing of the skin or eyes, loss of appetite, nausea or vomiting, pale stools, pain in upper right side of the stomach area, or dark urine. Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests before, during, and after your treatment to check your body's response to the combination of sofosbuvir, velpatasvir, and voxilaprevir. Talk to your doctor about the risk(s) of taking sofosbuvir, velpatasvir, and voxilaprevir.
Before taking sofosbuvir, velpatasvir, and voxilaprevir,
- tell your doctor and pharmacist if you are allergic to sofosbuvir, velpatasvir, and voxilaprevir, any other medications, or any of the ingredients in the combination of sofosbuvir, velpatasvir, and voxilaprevir tablets. Ask your pharmacist for a list of the ingredients.
- tell your doctor if you are taking rifampin (Rifadin, Rimactane, in Rifamate, in Rifater). Your doctor will probably tell you not to take sofosbuvir, velpatasvir, and voxilaprevir if you are taking rifampin.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: amiodarone (Nexterone, Pacerone); cholesterol-lowering medications (statins) such as atorvastatin (Lipitor, in Caduet), fluvastatin (Lescol), lovastatin (Altoprev), pitavastatin (Livalo), pravastatin (Pravachol), rosuvastatin (Crestor), simvastatin (Flolipid, Zocor, in Vytorin); cyclosporine (Gengraf, Neoral, Sandimmune); dabigatran (Pradaxa); digoxin (Lanoxin); H2 blockers such as cimetidine (Tagamet), famotidine (Pepcid), nizatidine (Axid), and ranitidine (Zantac); certain medications for human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) including atazanavir (Reyataz), efavirenz (Sustiva, in Atripla), lopinavir (in Kaletra), tenofovir (Viread, in Atripla, Complera, Stribild, Truvada, others), and tipranavir (Aptivus) when taken with ritonavir (Norvir); imatinib (Gleevec); irinotecan (Camptosar); lapatinib (Tykerb); methotrexate (Otrexup, Rasuvo, Xatmep); mitoxantrone; rifabutin (Mycobutin); rifapentine (Priftin); certain medications for seizures such as carbamazepine (Carbatrol, Epitol, Equetro, Tegretol), oxcarbazepine (Trileptal), phenobarbital, or phenytoin (Dilantin, Phenytek); sulfasalazine (Azulfidine); topotecan (Hycamtin); and warfarin (Coumadin, Jantoven). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with sofosbuvir and velpatasvir, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
- if you are taking aluminum or magnesium containing antacids (Maalox, Mylanta), take them 4 hours before or 4 hours after sofosbuvir, velpatasvir, and voxilaprevir.
- tell your doctor what herbal products you are taking, especially St. John's wort.
- tell your doctor if you have or have ever had any type of liver disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking sofosbuvir, velpatasvir, and voxilaprevir, call your doctor.
- difficulty falling asleep or staying asleep
- swelling of stomach area
- vomiting blood or material that looks like coffee grounds
- dark, black, or bloody stools