Medically reviewed by 
Apixaban (eliquis), a direct oral anticoagulant (DOAC) and factor Xa inhibitor, is primarily indicated for reducing the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. Additionally, it is utilized for thromboprophylaxis following hip or knee replacement surgery to prevent deep vein thrombosis (DVT) and subsequent pulmonary embolism (PE). It is also prescribed for the treatment of acute DVT and PE, as well as for secondary prevention to reduce the risk of recurrent thromboembolic events. Other potential off-label uses may exist, depending on emerging research and clinical practice.
Key Takeaways
Medical Use and Dosage: Apixaban (Eliquis) is a direct oral anticoagulant (DOAC) that reduces stroke risk in nonvalvular atrial fibrillation, prevents deep vein thrombosis (DVT) after hip or knee replacement, and treats acute and recurrent DVT or pulmonary embolism (PE). Standard dosing is 5 mg twice daily, with a reduced 2.5 mg dose for certain high-risk patients.
Safety and Warnings: Apixaban increases bleeding risk, particularly in those with bleeding disorders, liver/kidney disease, or undergoing spinal procedures. It is contraindicated in active pathological bleeding and should not be used in patients with prosthetic heart valves. Sudden discontinuation without alternative anticoagulation raises stroke risk.
Availability and Pricing: Eliquis is available online through pharmacies such as PlanetDrugsDirect ($338.99 for 168 tablets of branded Apixaban), DrugMart ($363.40 for 180 tablets), Amazon Pharmacy ($357.00 for 2.5mg), and Blink Health ($626.97). Prices vary between branded and generic equivalent options.
4 Places to Buy Eliquis (Apixaban) Online
If you’re looking to buy Eliquis (Apixaban) online, here are the best places to purchase it along with their pricing details:
Pharmacy | Price |
$338.99 for 168 tablets (5mg) branded Apixaban, $124.99 for 200 tablets (5mg) generic equivalent | |
DrugMart | $363.40 for 180 tablets (5mg) branded Apixaban, $264.21 for 168 tablets (5mg) generic equivalent |
Amazon Pharmacy | $357.00 for 2.5mg Eliquis (Bristol Myers Squibb) |
Blink Health | $626.97 |
Prices updated March 2025.
1. PlanetDrugsDirect — Top Pick
Price: $338.99 for 168 tablets (5mg) branded Apixaban, $124.99 for 200 tablets (5mg) generic equivalent.
Why Choose PlanetDrugsDirect?
Trusted CIPA-certified international pharmacy with competitive pricing.
Reliable customer service and safe medication sourcing.
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2. DrugMart
Price: $363.40 for 180 tablets (5mg) branded Apixaban, $264.21 for 168 tablets (5mg) generic equivalent.
Why Choose DrugMart?
Offers both branded and generic Apixaban at competitive rates.
Secure online ordering and licensed pharmacy verification.
3. Amazon Pharmacy
Price: $357.00 for 2.5mg Eliquis (Bristol Myers Squibb)
Why Choose Amazon Pharmacy?
Fast and reliable delivery options.
Convenient online ordering with customer reviews for reference.
4. Blink Health
Price: $626.97
Why Choose Blink Health?
Transparent pricing with potential savings on future refills.
Access to online prescription services.
Before Taking
Apixaban (eliquis) is contraindicated in individuals with a known allergy to the drug or active pathological bleeding due to surgery, injury, or other causes. It increases bleeding risk, particularly in those with inherited or disease-related bleeding disorders.
Precautionary considerations include:
Medical History: Patients with an artificial heart valve, bleeding disorders, antiphospholipid syndrome (especially triple-positive antibody test), liver disease, or kidney disease should consult their physician before use.
Spinal Cord Complications: Apixaban can lead to serious spinal hematoma and potential long-term paralysis when combined with spinal procedures such as a lumbar puncture or epidural anesthesia. Risk factors include:
Presence or recent removal of a spinal catheter
History of spinal surgery or multiple lumbar punctures
Recent spinal tap or epidural anesthesia
Concomitant use of NSAIDs (e.g., ibuprofen, naproxen, diclofenac)
Concurrent anticoagulant therapy
Physicians should carefully assess individual bleeding risks before prescribing apixaban, particularly in patients undergoing spinal procedures or those on concomitant anticoagulant therapy.
Dosage
Standard dose: 5 mg orally twice daily.
Reduced dose: 2.5 mg orally twice daily for patients with at least two of the following:
Age ≥ 80 years
Body weight ≤ 60 kg
Serum creatinine ≥ 1.5 mg/dL
Available in 2.5 mg and 5 mg tablets.
Storage Facts
Store at room temperature (20°C to 25°C / 68°F to 77°F).
Keep in a dry place, away from moisture and direct sunlight.
Side Effects
Most common side effects are related to bleeding, including major and fatal bleeding.
Other potential reactions include hypersensitivity reactions, such as skin rash and anaphylaxis.
Risk of bleeding increases with concurrent use of antiplatelet agents or NSAIDs.
Warnings
Discontinuation Warning: Stopping Eliquis without alternative anticoagulation increases stroke risk.
Bleeding Risk: Can cause serious, potentially fatal bleeding. Patients should be monitored for signs of blood loss.
Prosthetic Heart Valves: Use is not recommended.
Drug Interactions:
Strong inhibitors of CYP3A4 and P-gp increase blood levels of Eliquis (dose reduction may be required).
Strong inducers of CYP3A4 and P-gp decrease blood levels of Eliquis (avoid use).
Use in Specific Populations:
Not recommended during pregnancy or breastfeeding.
Not advised for patients with severe hepatic impairment.
Use with caution in patients with renal impairment.
For additional details or adverse event reporting, contact the FDA at 1-800-FDA-1088.
Rely on PlanetDrugsDirect.com to Buy Online Apixaban (Eliquis)
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Sources
U.S. Food and Drug Administration. Eliquis (apixaban) prescribing information. Published December 2012. Accessed March 7, 2025. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/202155s000lbl.pdf
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