Efficacy of Fluticasone Propionate Against Allergic Rhinitis

Allergic rhinitis is an inflammation of the nasal airways due to allergens, such as dust, animal dander and pollen. Overall, those with allergic rhinitis have a sensitized immune system. The allergen produces the antibody immunoglobulin E and typically causes symptoms like rashes, flu, watery eyes, itching and sneezing. Fluticasone propionate nasal spray is an intranasal corticosteroid to treat those with allergic rhinitis.

When the nasal passages are exposed to allergens, the cells in the nose begin to release chemicals that produce an allergic response. When the fluticasone propionate nasal spray is used, the fluticasone is absorbed directly by the cells. It prevents these cells from triggering the chemicals that cause an allergic response. However, fluticasone propionate doesn’t work right away; it can take up to four days to get the full effect. This is why doctors recommend using it prior to the allergy season, such as spring pollen. It also needs to be used on a regular basis to keep nasal inflammation under control.

Clinical Studies on the Efficacy of Fluticasone for Allergic Rhinitis

According to the U.S. National Library of Medicine National Institutes of Health, double-masked studies have been done to confirm the efficacy of fluticasone nasal spray. In one study, 304 patients with allergic rhinitis received 200 micrograms daily, 5 milligrams orally or a placebo. Plasma fluticasone concentrations were taken daily and after two weeks of treatment. The group was assessed weekly by clinicians, and each patient recorded daily symptoms. After two weeks, the placebo group and 5-milligram group had higher concentrations of plasma fluticasone propionate. When compared to the nasal spray group, nasal symptom scores were significantly higher for itching, sneezing, nasal obstruction and rhinorrhea. This study indicated that the efficacy of fluticasone propionate nasal spray is more effective than placebo and oral administration after systemic absorption.

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