Medically reviewed by 
TRINTELLIX (vortioxetine) is a prescription antidepressant used to treat Major Depressive Disorder (MDD) in adults. It is taken orally once daily and works by modulating serotonin activity in the brain through a multimodal mechanism. TRINTELLIX (vortioxetine) is typically prescribed for long-term use, making affordability and consistent access key concerns for patients.
Without insurance or discounts, a one-month supply of TRINTELLIX (vortioxetine) can cost over $530 at retail pharmacies in the United States.
Key Takeaways
Online Pharmacies Offer Up to 55% Savings: CIPA-certified pharmacies list TRINTELLIX (vortioxetine) at under $250 for 84 tablets, significantly below U.S. retail prices. Purchase from Planet Drugs Direct.
U.S. Pharmacy Prices Average $428–$539 for 30 Tablets: CVS and Walgreens charge approximately $17–$18 per tablet for the 20mg strength.
Copay Assistance Available for Commercially Insured Patients: The TRINTELLIX Savings Card may reduce eligible patients’ out-of-pocket costs to as little as $0.
Medicare Covers TRINTELLIX (vortioxetine), But Costs Vary: While generally covered under Part D, actual costs depend on benefit phase and plan structure.
Cheapest Online Pharmacies for TRINTELLIX (Vortioxetine)
CIPA-certified international pharmacies offer significantly lower prices for patients who pay out of pocket. These pharmacies require a valid prescription and typically ship from licensed facilities in Canada or other regulated countries.
Pharmacy | Prescription Required | Price (30 Tablets) | Dosage | Website |
Planet Drugs Direct | Yes | ~$88.93 | 20mg | |
DrugMart | Yes | ~$200.40 | 20mg | |
Amazon Pharmacy | Yes | $428.15 | 20mg |
Prices as of July 1, 2025. Note: Planet Drugs Direct and DrugMart prices reflect 84-tablet packages. Prorated values shown for monthly comparisons.
U.S. Retail Pharmacy Prices for TRINTELLIX (Vortioxetine)
Below are examples of typical U.S. retail prices for TRINTELLIX (vortioxetine) 20mg tablets (30-day supply) as of July 1, 2025:
Pharmacy | Retail Price (30 Tablets) | Price per Tablet |
Walgreens | $521.21 | $17.37 |
CVS | $539.42 | $17.98 |
CVS inside Target | $539.42 | $17.98 |
Prices may vary by region and pharmacy. Discounts or coupons may be available depending on insurance and location.
How to Save on TRINTELLIX (Vortioxetine)
Here's how to save on TRINTELLIX (vortioxetine):
1. Use the TRINTELLIX Savings Card
Commercially insured patients may qualify for the TRINTELLIX Savings Card program, which can reduce the out-of-pocket cost per prescription.
Pay as little as $0 per month
Not valid for patients with Medicare, Medicaid, TRICARE, or other government insurance
Not valid for uninsured (cash-pay) patients
Apply or learn more. Note: Patients must be 18 years or older and have a valid prescription for TRINTELLIX (vortioxetine).
2. Medicare Coverage and Considerations
TRINTELLIX (vortioxetine) is generally covered under Medicare Part D plans, though costs may vary:
Coverage: Most Medicare Part D and Advantage plans include TRINTELLIX (vortioxetine) on their formularies.
Cost Factors: Your out-of-pocket cost depends on your deductible, tier placement, and benefit phase (initial coverage, gap, or catastrophic).
Prior Authorization: Most plans do not require prior authorization, but it’s advisable to verify with your specific plan.
Extra Help: If you qualify for Medicare's Extra Help program, your copays may be reduced to as low as $4–$9 per fill.
For the most accurate estimate, review your plan's formulary or contact your Medicare provider directly.
3. Use CIPA-Certified International Pharmacies
Ordering TRINTELLIX (vortioxetine) through a CIPA-certified pharmacy is a cost-effective option for patients who are uninsured or paying entirely out of pocket.
Save up to 55% compared to retail prices
Valid prescription required
Longer supply quantities (84 tablets) available at lower per-tablet costs
CIPA-certified online pharmacies:
DrugMart: 84 tablets for $561.12
Shipping times and refill procedures vary by provider and country of origin.
Annual Cost Comparison for TRINTELLIX (Vortioxetine)
Based on your purchase location and pharmacy, the annual cost of TRINTELLIX (vortioxetine) could be:
Purchase Method | Monthly Estimate | Annual Estimate |
U.S. Retail Pharmacy | $521 – $539 | ~$6,250 – $6,470 |
CIPA-certified Online Pharmacy | ~$89 – $200 | ~$1,065 – $2,400 |
Commercial Copay Card | As low as $0 | Varies by plan |
Medicare Part D | $4 – $933 | ~$48 – $11,000+ |
Common Questions About TRINTELLIX (Vortioxetine)
Common questions and answers about TRINTELLIX (vortioxetine):
Is TRINTELLIX (vortioxetine) covered by Medicare?
Yes. Most Medicare Part D and Advantage plans cover TRINTELLIX (vortioxetine), but costs vary depending on the plan and benefit phase.
Can I use the TRINTELLIX (vortioxetine) Savings Card if I have Medicare?
No. The savings card is not available to patients with Medicare, Medicaid, or other government-funded insurance programs.
How much does TRINTELLIX (vortioxetine) cost without insurance?
Retail pharmacy prices range from $521 to $539 per 30-tablet supply. CIPA-certified pharmacies offer comparable supplies for as little as $89 per month.
Do I need a prescription to buy TRINTELLIX (vortioxetine) online?
Yes. All reputable pharmacies, including international options, require a valid prescription for TRINTELLIX (vortioxetine).
Rely on PlanetDrugsDirect.com to Buy Online Prescription Trintellix
As a trusted prescription referral service, we offer important benefits whenever you order online. Each of our partner pharmacies and/or government-approved dispensaries is committed to providing the best experience possible of any online prescription referral service on the internet. We offer:
Low prices
Quick turn-around times
Generic and brand-name medications
Unparalleled customer service
Sources
Takeda Pharmaceuticals USA, Inc. TRINTELLIX (vortioxetine) Patient Brochure. Accessed July 5, 2025. https://us.trintellix.com/content/dam/takeda/imported/trintellix/pdfs/cons-patient-brochure.pdf
Takeda Pharmaceuticals USA, Inc. TRINTELLIX Savings and Support Program. Accessed July 5, 2025. https://us.trintellix.com/savings-support/savings-card
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