Byetta (Exenatide Synthetic)
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Exenatide Synthetic Information
(ex en' a tide)Exenatide injection may increase the risk that you will develop tumors of the thyroid gland, including medullary thyroid carcinoma (MTC; a type of thyroid cancer). Laboratory animals who were given exenatide developed tumors, but it is not known if this medication increases the risk of tumors in humans. Tell your doctor if you or anyone in your family has or has ever had MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2; condition that causes tumors in more than one gland in the body). If so, your doctor will probably tell you not to use exenatide injection. If you experience any of the following symptoms, call your doctor immediately: a lump or swelling in the neck; hoarseness; difficulty swallowing; or shortness of breath. Keep all appointments with your doctor and the laboratory. Your doctor may order certain tests to check your body's response to exenatide. Talk to your doctor about the risks of using exenatide injection.
Before using exenatide injection,
- tell your doctor and pharmacist if you are allergic to exenatide, any other medications, or any of the ingredients in exenatide injection. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. It is especially important to tell your doctor about all the medications you take by mouth because exenatide may change the way your body absorbs these medications. Be sure to mention any of the following: angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril, (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavika); diuretics ('water pills'); aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); lovastatin (Altoprev, in Advicor); medications for high blood pressure ; insulin or other medications to treat diabetes such as sulfonylureas such as chlorpropamide (Diabinese), glimepiride (Amaryl, in Avandaryl, in Duetact), glipizide (Glucotrol), glyburide (DiaBeta, in Glucovance), tolazamide, and tolbutamide, and warfarin (Coumadin, Jantoven). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- if you are taking oral contraceptives (birth control pills) or antibiotics, take them at least 1 hour before you use exenatide injection. If you have been told to take these medications with food, take them with a meal or snack at a time when you do not use exenatide.
- tell your doctor if you drink or have ever drunk large amounts of alcohol, and if you are experiencing nausea, vomiting, and diarrhea or think you may be dehydrated, or if you develop these symptoms at any time during your treatment. Also tell your doctor if you have ever had a kidney transplant or if you have or have ever had severe stomach problems, including gastroparesis (slowed movement of food from the stomach to the small intestine) or other problems digesting food; pancreatitis (swelling of the pancreas), gallstones (solid deposits that form in the gallbladder), or a high level of triglycerides (fats) in the blood, or pancreas, liver, or kidney disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while using exenatide, call your doctor.
- ask your doctor about the safe use of alcoholic beverages while you are taking exenatide.
- ask your doctor what to do if you get sick, develop an infection or fever, experience unusual stress, or are injured. These conditions can affect your blood sugar and the amount of exenatide you may need.
- jittery feeling
- ongoing pain that begins in the upper left or middle of the stomach but may spread to the back with or without vomiting
- difficulty breathing or swallowing
- injection-site pain, swelling, blisters, itching, or nodules
- swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
- changes in the color or amount of urine
- urinating more or less often than usual
- swelling of the arms, hands, feet, ankles, or lower legs
- decreased appetite