Estrogens, Conjugated / Medroxyprogesterone Acetate
(Rx) - indicates only available by prescription
To comply with Canadian International Pharmacy Association regulations you are permitted to order a 3 month or 100 day supply based on your personal prescription. read more
Prempro is used in the treatment of menopausal symptoms and bone loss (osteoporosis) in those at high risk. This is a medication made up of a combination of hormones (progestin and estrogen). This medication is generally only used as second line for both conditions once other treatments have failed. There may be other conditions where Prempro is a good choice of medication for you and so do not be surprised if your doctor prescribes you this medication for another condition. However you can expect a full explanation for why he or she has done so.
As is the case with all drugs, it is vital that you carefully follow the instructions given to you by your doctor. In most cases this will be written on the label of the medicine bottle or box and you must read this information very carefully. If you do happen to have any questions about how to take this medicine then you should talk to your pharmacist, nurse or doctor and they will be happy to help you. You must not crush, break or chew this medicine and should instead swallow it whole with a glass of water. It is not important if you take this medicine with food or on an empty stomach, however you must not mix the medicine in with your food or with any liquid. This medicine may be taken with food or right after a meal to prevent stomach upset. Where you keep the medicine is very important and in this case it must be stored at room temperature (77 degrees F) away from the sun and in the bottle or box provided or in an airtight container. You must take the medicine as directed by your doctor and if you can take it at the same time everyday i.e. at breakfast time, then that may help you to remember. It is very important that you take this medicine everyday as directed and do not miss a dose, even if you are feeling better. Failure to take your medicine as directed will likely result in the worsening of your symptoms. In the unfortunate scenario that you do forget to take a dose, you must take the missed dose as soon as you remember unless this is near the time of your next dose. In this case you should just forget about the missed dose and carry on with your normal schedule, as you must never take two doses of a single medication at the same time. If you have any concerns then you should contact your pharmacist, nurse or doctor for more information.
First and foremost you should not take Prempro if you have experienced an allergic or other adverse reaction to it or any other ingredient that is used in the production of Prempro. If you are worried that you may have had an adverse reaction to Prempro in the past then you should discuss this with your doctor. Stopping a medicine suddenly will often result in a worsening of symptoms and side effects and in most cases your doctor will want you to come off a medicine slowly, a process known as tapering. There may be tests that are required by your doctor to check for side effects and/or monitor how effective the medicine is for you, however your doctor will talk to you about what is required. It is important to attend all laboratory and doctor appointments while you are taking Prempro and additional appointments may be necessary when a change to the dose is made and during the initial starting period. You should avoid performing tasks such as driving; operating heavy machinery or any other dangerous activities until you know what effects this medicine has on you. Prempro can make you feel dizzy therefore you should wait until you know what effects it has on your body before you partake in the above activities. You should never change or alter the dose of any medication unless you have talked it through with your doctor. It is vital that you notify your doctor or pharmacist before you begin any new medication, even if it is only one brought over the counter.
Prempro may have adverse effects on the fetus in pregnant women and so all women who may be thinking about getting pregnant should weigh up the pros and cons of taking this medicine during pregnancy with their doctor. Also there is not enough research for us to know if Prempro is excreted in the breast milk and so general advice at this time is to not breast-feed while on this medication.
It is important to note that Prempro can cause you to be extra sensitive to sunlight and cause dark patches known as melasma to form on your face. You should avoid over exposure to the sun until it is clear how your body will react to this medicine. You must wear protective clothing as well as sunscreen if you intend to be in the sun for long periods of time. It is important that before you undergo any dental work or surgery of any kind that you let the dentist or doctor know that you are taking this medication. You must let the laboratory know that you are on this medicine if you undergo any blood tests as Prempro may affect the results. You must not smoke while taking Prempro or your risk of heart disease and blood clots is higher than with just smoking alone. If you become dizzy while on this medication you should sit or stand up slowly and then contact your doctor. You should also try to avoid drinking any alcohol while taking this medication.
Your doctor at least once per year while on this medicine should perform a complete physical examination. You should also have mammograms when your doctor recommends. If you are to have surgery or will be confined to a chair or bed for a long period of time then you will likely require special precautions to protect you from getting a blood clot.
Prempro Side Effects
As is the case with most drugs Prempro is not without its side effects. Some of the things that you may notice when taking this medication include: breast tenderness, decreased or increased interest in sex, weight changes, nausea, fatigue, changes in sleep patterns, irritability, bloating, stomach upset, headache, lightheadedness, or dizziness. These may be minor and go away during the course of treatment, however if they do bother you then you must talk to your doctor. Prempro was prescribed to you, as your doctor believes that the benefits will outweigh the side effects and so it is usual to expect some symptoms. However these symptoms should not cause you major discomfort and if this is the case then please talk to your doctor. You must talk to your doctor as soon as possible if you experience any yellowing of the skin or eyes, unusual vaginal discharge, odor or itching, changes in vaginal bleeding, swelling of the feet or hands, breast lumps, changes in vision, slurred speech, weakness of one side of the body, difficulty breathing, chest pain, sudden severe headache, calf swelling or pain, or mood or mental changes. Fortunately it is uncommon for someone to have an allergic reaction to this medicine, however they do occur and if you notice severe dizziness, a rash, itching, trouble breathing or swelling then you must seek immediate medical attention. If you experience any symptoms that worry you, even if they are not listed above, then it is vital that you talk to your doctor, pharmacist or nurse about it.
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