Changes coming to U.S. import regulations, effective August 29th, 2025. All shipments may be affected. Read more for continued updates.
(Omeprazole)
Prescription required. Can not be split. Product of New Zealand. Shipped from New Zealand. Prilosec is also marketed internationally under the name Losec.
Prescription required. Can not be split. Product of UK/EU. Shipped from United Kingdom.
Prescription required. Can not be split. Product of New Zealand. Shipped from New Zealand. Prilosec is also marketed internationally under the name Losec.
Can not be split. Product of New Zealand. Shipped from New Zealand.
Prescription required. Can not be split. Product of New Zealand. Shipped from New Zealand. Prilosec is also marketed internationally under the name Losec.
Prescription required. Can not be split. Product of UK/EU. Shipped from United Kingdom.
Prilosec (omeprazole) is a type of medication known as a proton pump inhibitor (PPI), which works by reducing the production of acid in the stomach. It’s frequently used to treat conditions caused or complicated by too much stomach acid, including gastroesophageal reflux disease (GERD), erosive esophagitis, and stomach ulcers. When managing infrequent heartburn, alternative medications like antacids or H2 antihistamines (e.g., famotidine) are often recommended before utilizing PPIs like omeprazole.
GERD (Gastroesophageal Reflux Disease): Provides relief from persistent heartburn, acid regurgitation, and inflammation caused by stomach acid backing up into the esophagus.
Erosive Esophagitis: Assists in healing damage to the esophageal lining due to prolonged acid exposure.
H. pylori-Related Ulcers: Used alongside antibiotics to manage ulcers associated with Helicobacter pylori, a bacterial strain that contributes to ulcer formation.
Frequent Heartburn: Prilosec OTC is used in adults for heartburn occurring two or more days per week and is taken in 14-day treatment cycles. When used over the counter, do not continue use for longer than two weeks without consulting a healthcare provider, even if symptoms persist.
To comply with Canadian International Pharmacy Association regulations you are permitted to order a 3-month supply or the closest package size available based on your personal prescription. read more
Doctors prescribe Prilosec to manage both short-term and long-standing gastrointestinal conditions tied to acid overproduction. It is especially helpful when other acid reducers like antacids or H2 blockers are not providing adequate relief. By targeting the source of acid secretion in the stomach, Prilosec helps:
Ease symptoms like heartburn, sour stomach, and indigestion
Heal acid-related damage in the esophagus or stomach lining
Prevent ulcer recurrence
Control chronic digestive issues associated with high stomach acidity
Follow the dosing instructions exactly as provided by your healthcare provider or listed on the packaging.
Prescription strength: Typically taken once daily before eating.
OTC version: Taken daily for 14 consecutive days; do not exceed this duration without medical guidance. Wait at least four months before starting another OTC course.
Capsules should be swallowed whole. If swallowing is difficult, the capsule can be opened and the contents mixed with applesauce—consume immediately without chewing.
Powder forms may require mixing with water for oral use or administration via NG tube.
Continue treatment for the full recommended duration, even if your symptoms improve early on.
Take your missed dose as soon as you remember, unless it’s almost time for your next one.
Never take a double dose to make up for a missed one.
Symptoms may include confusion, rapid heartbeat, vision disturbances, or drowsiness.
Contact Poison Control (1-800-222-1222) in the US or 1-844-764-7669 in Canada, or seek emergency care right away.
Headache
Nausea or vomiting
Abdominal discomfort or bloating
Diarrhea
Cold-like symptoms such as sneezing and sore throat
Kidney issues: Less frequent urination, swelling (often around feet or ankles), or presence of blood in urine
Severe diarrhea: Could indicate an infection, especially if watery or bloody
Lupus-like reactions: Joint pain and rash that worsens with sun exposure
Low magnesium levels: Can cause cramps, irregular heartbeat, or seizures
Severe allergic reactions: Swelling, rash, trouble breathing
Bone health concerns: Increased risk of fractures (hip, wrist, spine) with long-term use
B-12 deficiency: More likely to occur with extended use over several years
Stomach polyps: Long-term use may increase the chance of fundic gland polyps
You are allergic to omeprazole or similar PPIs (such as Nexium, Protonix, or Prevacid)
You've previously experienced serious allergic or kidney issues after taking a PPI
You’re currently taking rilpivirine, a medication used to treat HIV
Impaired liver or kidney function
Low magnesium levels
Bone loss (osteopenia) or diagnosed osteoporosis
Unexplained weight loss or recurring stomach discomfort
Swallowing difficulties or signs of gastrointestinal bleeding (e.g., dark stools or blood in vomit)
Need for prolonged acid suppression therapy
Generally considered safe during pregnancy, but always consult your doctor.
If breastfeeding, monitor your baby for potential side effects and discuss use with your provider.
Keep at room temperature (68–77°F / 20–25°C), in a dry place away from direct heat and moisture.
Ensure the bottle is securely closed.
Avoid storing the medication in humid environments like the bathroom.
Dispose of expired or unused medicine through a pharmacy take-back program or follow local disposal instructions.
The effectiveness of some medications may be altered when taken alongside Prilosec, especially those affected by changes in stomach acidity.
Be sure to inform your provider if you’re taking:
Digoxin (used for heart conditions)
Clopidogrel (a blood thinner)
Methotrexate
St. John’s Wort
Certain antibiotics (like amoxicillin or clarithromycin)
Medications processed by CYP2C19 liver enzymes (e.g., citalopram, etc.)
Avoid anti-diarrhea medications if you develop severe or bloody stools while using Prilosec—consult your doctor first.
Always provide your doctor with a comprehensive list of all medications, herbal products, and supplements you are currently using to help prevent harmful interactions.
The content on this page is for informational and educational purposes only and does not constitute professional medical advice. Patients should not use the information presented on this page for diagnosing a health-related issue or disease. Before taking any medication or supplements, patients should always consult a physician or qualified healthcare professional for medical advice or information about whether a drug is safe, appropriate or effective.
