Before taking rifabutin,
tell your doctor and pharmacist if you are allergic to rifabutin, rifampin (Rifadin, Rimactane, in Rifamate, Rifater), rifapentine (Priftin), rifaximin (Xifaxan), any other medications, or any of the ingredients in rifabutin capsules. Ask your pharmacist for a list of the ingredients.
tell your doctor if you are taking delavirdine (Rescriptor) or voriconazole (Vfend). Your doctor will probably tell you not to take rifabutin if you are taking one or more of these medications.
tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: clarithromycin (Biaxin, in Prevpac); fluconazole (Diflucan); HIV protease inhibitors such as atazanavir (Reyataz, in Evotaz), darunavir (Prezista, in Prezcobix), fosamprenavir (Lexiva), indinavir (Crixivan), lopinavir (in Kaletra), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra, Technivie, Viekira Pak), saquinavir (Invirase), and tipranavir (Aptivus); itraconazole (Sporanox, Onmel); and posaconazole (Noxafil). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with rifabutin, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
tell your doctor if you have or have ever liver or kidney disease .
tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking rifabutin, call your doctor.
tell your doctor if you are taking or using hormonal contraceptives (birth control pills, patches, rings, implants, and injections) to prevent pregnancy. Rifabutin may interfere with the action of hormonal contraceptives. Talk to your doctor about other methods of birth control that will work for you.
tell your doctor if you wear soft contact lenses. Rifabutin may cause permanent brown-orange stains on your contact lenses.