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(floo' ta mide)Flutamide may cause liver damage that can be serious or life-threatening. Tell your doctor if you have or have ever had liver disease. If you experience any of the following symptoms, call your doctor immediately: nausea, vomiting, loss of appetite, extreme tiredness, flu-like symptoms, muscle aches, soreness, pain in the upper right part of the stomach, yellowing of the skin or eyes, or dark urine. Keep all appointments with your doctor and the laboratory. Your doctor will order certain blood tests to check how well your liver is working before you begin taking flutamide, every month for the first 4 months of your treatment, and periodically for as long as your treatment continues. Talk to your doctor about the risks of taking flutamide.