Trametinib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
sores on the mouth and tongue
loss of appetite
change in ability to taste food
Some side effects can be serious. If you experience any of these symptoms, stop taking trametinib and call your doctor immediately:
unusual bleeding or bruising
bloody or black, tarry stools
coughing up or vomiting blood or material that looks like coffee grounds
rapid, irregular, or pounding heartbeat
swelling of the face, arms, legs, ankles, or feet
dizziness. lightheadedness, or weakness
shortness of breath
change in vision, including seeing halos (blurred outline around objects) or colored dots
loss of vision
dry, red, or swollen eyes
rash, red skin, or pimples
blisters, ulcers, or sores on the skin or nails
tingling, burning, redness, swelling, peeling or flaking, blisters, or sores on the palms of the hands or soles of the feet
Trametinib may increase the risk that you will develop other cancers, including new skin cancers. Talk to your doctor about the risks of taking this medication.
Trametinib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).