Before taking venetoclax,
tell your doctor and pharmacist if you are allergic to venetoclax, any other medications, or any of the ingredients in venetoclax tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
tell your doctor if you are taking clarithromycin (Biaxin, in Prevpac), conivaptan (Vaprisol), indinavir (Crixivan), itraconazole (Onmel, Sporanox), ketoconazole, lopinavir (in Kaletra), posaconazole (Noxafil), ritonavir (Norvir, in Kaletra, Technivie, Viekira Pak), or voriconazole (Vfend). Your doctor may tell you not to take venetoclax if you are taking one or more of these medications.
tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: amiodarone (Cordarone, Nexterone, Pacerone), azithromycin (Zithromax, Zmax), bosentan (Tracleer), captopril, carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril), carvedilol (Coreg), ciprofloxacin (Cipro), cyclosporine (Gengraf, Neoral, Sandimmune), digoxin (Digitek, Lanoxin), diltiazem (Cardizem, Cartia XT, Diltzac, Taztia, Tiazac), dronedarone (Multaq), efavirenz (Sustiva, in Atripla), erythromycin (E.E.S., Eryc, Eryped, Ery-tab, Erythrocin), etravirine (Intelence), everolimus (Afinitor, Zortress), felodipine, fluconazole (Diflucan), modafinil (Nuvigil, Provigil), nafcillin (Nallpen), phenytoin (Dilantin, Phenytek), quinidine (in Nuedexta), ranolazine (Ranexa), rifampin (Rifadin, Rimactane, in Rifamate, Rifater), sirolimus (Repamune), ticagrelor (Brilinta), verapamil (Calan, Covera-HS, Verelan, in Tarka), or warfarin (Coumadin, Jantoven). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with venetoclax, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
tell your doctor what herbal products you are taking, especially quercetin, or Saint John's wort.
tell your doctor if you have or have ever had problems with your levels of potassium, phosphorus, or calcium in your blood; high levels of uric acid in your blood; gout (a type of arthritis caused by crystals deposited in the joints); or kidney or liver disease.
tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you can become pregnant, you will need to have a pregnancy test before beginning treatment with venetoclax. You should not become pregnant during your treatment and for 30 days after your last dose. Talk to your doctor about birth control methods that you can use during your treatment. If you become pregnant while taking venetoclax, call your doctor.
Do not have any vaccinations before, during, or after treatment with venetoclax without talking to your doctor.
You should know that you may experience tumor lysis syndrome (TLS; a condition caused by the fast breakdown of cancer cells that can cause kidney failure and other complications) during your treatment with venetoclax. This is more likely to happen when you are first starting treatment, and each time your dose is increased. To help reduce your risk of experiencing TLS you should drink at least 6-8 glasses (48-64 ounces) of water a day for 2 days before and on the day of your first dose, and each time your dose is increased. In addition your doctor will give you a medication to take before starting and during your treatment to help prevent this side effect. If you experience any of the following symptoms of TLS call your doctor immediately: fever, chills, nausea, vomiting, confusion, shortness of breath, seizures, irregular heartbeat, dark or cloudy urine, unusual tiredness, or muscle or joint pain.