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(Rifaximin)
Prescription required. Can not be split. Product of UK/EU. Shipped from United Kingdom. Xifaxan is also marketed internationally under the name Xifaxanta.
Prescription required. May be split. Product of India. Shipped from Mauritius.
Prescription required. May be split. Product of India. Shipped from Mauritius.
Prescription required. Can not be split. Product of Italy. Shipped from Australia.
Prescription required. May be split. Product of India. Shipped from Mauritius.
Xifaxan is a non-absorbable antibiotic that acts locally in the intestines to fight specific bacterial infections. Unlike many antibiotics, it passes through the digestive tract without entering the bloodstream, making it ideal for gastrointestinal conditions. It is not effective for infections in other areas of the body.
Xifaxan is commonly used for:
Traveler’s Diarrhea: Caused by Escherichia coli (E. coli) in adults and children ≥12 years.
Irritable Bowel Syndrome with Diarrhea (IBS-D): For adults experiencing chronic diarrhea-predominant IBS.
Hepatic Encephalopathy: To reduce the recurrence of brain function decline due to liver failure by reducing levels of toxin-producing bacteria in the gut.
It may also be prescribed for other conditions as determined by your healthcare provider.
To comply with Canadian International Pharmacy Association regulations you are permitted to order a 3-month supply or the closest package size available based on your personal prescription. read more
Dosage information and scheduling should be provided by the prescribing healthcare provider. While your individual recommendation may vary, many dosing schedules are similar to those recommended by the manufacturer:
For IBS-D: 550 mg taken three times a day for 14 days. If symptoms return, this regimen may be used again.
For Traveler’s Diarrhea: 200 mg taken three times a day for 3 days.
For Hepatic Encephalopathy: 550 mg taken twice a day. Daily use is recommended long-term for the prevention of symptoms.
Condition | Dosage | Duration |
Irritable Bowel Syndrome | 550 mg, 3 times/day | 14 days |
Traveler’s Diarrhea | 200 mg, 3 times/day | 3 days |
Hepatic Encephalopathy | 550 mg, twice/day | Long-term use |
Take Xifaxan exactly as prescribed. Follow your doctor’s instructions and read all medication guides.
With or without food.
Do not stop early—even if symptoms improve—complete the full course. This helps ensure infections do not return and helps prevent antibiotic resistance.
Traveler’s Diarrhea: 200 mg 3×/day for 3 days
Hepatic Encephalopathy: 550 mg 2×/day
IBS-D: 550 mg 3×/day for 14 days (can be repeated up to 2 times if symptoms return)
Do NOT use Xifaxan if you:
Are allergic to rifaximin, rifampin, rifabutin, or rifapentine
Tell your doctor if you have:
Liver disease (additional caution is needed in individuals managing severe liver disease)
Diarrhea with fever, or watery/bloody stools
A positive pregnancy test or are breastfeeding
Children under 12 should not use Xifaxan.
There are no specific food restrictions, and Xifaxan may be taken with or without meals.
Avoid anti-diarrheal medications unless directed by a healthcare provider, especially if diarrhea is watery or bloody.
Take the missed dose as soon as you remember.
If it’s almost time for the next dose, skip the missed one—do not double up.
Contact your doctor if unsure how to proceed.
Common Side Effects:
Many of the symptoms reported by individuals taking Xifaxan are also commonly experienced when managing the the conditions being treated. If any symptoms persist or worsen rather than improve, contact your healthcare provider.
Swelling of hands or feet
Nausea
Dizziness
Fatigue
Abdominal swelling
Skin rash
Abdominal pain
Anemia
Serious Side Effects (seek immediate help):
Allergic reactions: hives, swelling of face/lips/throat, breathing trouble
Severe stomach pain or bloody diarrhea
Fever
Rapid weight gain, bloating, or trouble breathing (sometimes due to fluid buildup in the abdomen)
Report side effects to the FDA at 1-800-FDA-1088.
Store at room temperature (68°F to 77°F or 20°C to 25°C)
Keep away from moisture and heat
Do not freeze
Keep out of reach of children
Do not share Xifaxan with others, even if symptoms are similar.
Xifaxan does not treat viral infections such as colds or flu.
Call your doctor if symptoms don’t improve within 24–48 hours or worsen.
Possible drug interactions include:
Cyclosporine, ketoconazole, warfarin
Antibiotics (clarithromycin, erythromycin)
Antivirals (ritonavir, saquinavir)
Heart medications (amiodarone, quinidine, verapamil)
Always provide your doctor with a complete list of medications, supplements, and herbs you’re using.
The content on this page is for informational and educational purposes only and does not constitute professional medical advice. Patients should not use the information presented on this page for diagnosing a health-related issue or disease. Before taking any medication or supplements, patients should always consult a physician or qualified healthcare professional for medical advice or information about whether a drug is safe, appropriate or effective.
