Before taking mefloquine,
tell your doctor and pharmacist if you are allergic to mefloquine, quinidine (Quinadex), quinine (Qualaquin), any other medications, or any of the ingredients in mefloquine tablets.
tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention any of the following: anticoagulants ('blood thinners'); antidepressants such as amitriptyline (Elavil), amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Adapin, Sinequan), imipramine (Tofranil), nortriptyline (Aventyl, Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil); antihistamines; calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem, Dilacor, Tiazac), felodipine (Plendil), isradipine (DynaCirc), nicardipine (Cardene), nifedipine (Adalat, Procardia), nimodipine (Nimotop), nisoldipine (Sular), and verapamil (Calan, Isoptin, Verelan); beta blockers such as atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), and propranolol (Inderal); chloroquine (Aralen); medication for diabetes, mental illness, seizures and upset stomach; medications for seizures such as carbamazepine (Tegretol), phenobarbital (Luminal), phenytoin (Dilantin), or valproic acid (Depakene); and rifampin (Rifadin, Rimactane, in Rifamate, in Rifater). Also tell your doctor or pharmacist if you are taking the following medications or have stopped taking them within the past 15 weeks: halofantrine (Halfan; no longer available in the United States) or ketoconazole (Nizoral). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
tell your doctor if you have or have ever had any of the conditions mentioned in the IMPORTANT WARNING section or any of the following: a prolonged QT interval (a rare heart problem that may cause irregular heartbeat, fainting, or sudden death), anemia (a lower than normal number of red blood cells), or eye, liver or heart disease.
tell your doctor if you are pregnant or plan to become pregnant, or are breast-feeding. You should use birth control while you are taking mefloquine and for 3 months after you stop taking it. If you become pregnant while taking mefloquine, call your doctor.
you should know that mefloquine may make you drowsy and dizzy. These symptoms may continue for a while after you stop taking mefloquine. Do not drive a car or operate machinery until you know how this medication affects you.
you should know that mefloquine decreases your risk of becoming infected with malaria but does not guarantee that you will not become infected. You still need to protect yourself from mosquito bites by wearing long sleeves and long pants and using mosquito repellant and a bed net while you are in an area where malaria is common.
you should know that the first symptoms of malaria are fever, chills, muscle pain, and headaches. If you are taking mefloquine to prevent malaria, call your doctor immediately if you develop any of these symptoms. Be sure to tell your doctor that you may have been exposed to malaria.
you should plan what to do in case you experience serious side effects from mefloquine and have to stop taking the medication, especially if you are not near a doctor or pharmacy. You will have to get another medication to protect you from malaria. If no other medication is available, you will have to leave the area where malaria is common, and then get another medication to protect you from malaria.
if you are taking mefloquine to treat malaria, your symptoms should improve within 48 to 72 hours after you finish your treatment. Call your doctor if your symptoms do not improve after this time.
do not have any vaccinations (shots) without talking to your doctor. Your doctor may want you to finish all of your vaccinations 3 days before you start taking mefloquine.