Before receiving paliperidone extended-release injection,
tell your doctor and pharmacist if you are allergic to paliperidone, risperidone (Risperdal, Risperdal Consta), any other medications, or any of the ingredients in paliperidone extended-release injection. Ask your pharmacist for a list of the ingredients.
tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: other antipsychotic medications such as chlorpromazine, risperidone (Risperdal, Risperdal Consta), and thioridazine; medications for blood pressure; carbamazepine; diuretics ('water pills'); dopamine agonists such as bromocriptine (Cycloset, Parlodel), cabergoline, levodopa and carbidopa (Duopa, Rytary, Sinemet, others), pramipexole (Mirapex), ropinirole (Requip), and rotigotine (Neupro); fluoroquinolone antibiotics such as gatifloxacin (Zymar, Zymaxid) and moxifloxacin (Avelox); medications for irregular heartbeat such as amiodarone (Cordarone, Nexterone, Pacerone), procainamide, quinidine (in Nuedexta); rifampin; and sotalol (Betapace, Sorine). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
tell your doctor what herbal products you are taking, especially St. John's wort.
tell your doctor if you have a low level of potassium or magnesium in your blood, a low number of white blood cells, or if any other medication has ever caused a decrease in your white blood cells. Also tell your doctor if you have or have ever had seizures, a stroke, a ministroke, a heart attack, heart failure, an irregular heartbeat, long QT syndrome (condition that increases the risk of developing an irregular heartbeat that may cause fainting or sudden death), uncontrolled movements of your tongue, face, mouth, or jaw, trouble keeping your balance, Parkinson's disease (PD; a disorder of the nervous system that causes difficulties with movement, muscle control, and balance), Lewy body dementia (a condition in which the brain develops abnormal protein structures, and the brain and nervous system are destroyed over time), difficulty swallowing, dyslipidemia (high cholesterol levels), heart, liver, or kidney disease, or if you or anyone in your family has or has ever had diabetes. Tell your doctor if you have severe vomiting, diarrhea or signs of dehydration now, or if you develop these symptoms at any time during your treatment.
tell your doctor if you are pregnant, if you plan to become pregnant, or if you are breastfeeding. If you become pregnant during your treatment with paliperidone extended-release injection, call your doctor.
you should know that receiving paliperidone extended-release injection may make you drowsy and may affect your ability to think clearly, make decisions, and react quickly. Do not drive a car or operate machinery at other times during your treatment with paliperidone extended-release injection until you know how this medication affects you.
you should know that you may experience hyperglycemia (increases in your blood sugar) while you are receiving this medication, even if you do not already have diabetes. If you have schizophrenia, you are more likely to develop diabetes than people who do not have schizophrenia, and receiving paliperidone extended-release injection or similar medications may increase this risk. Tell your doctor immediately if you have any of the following symptoms during your treatment: extreme thirst, frequent urination, extreme hunger, blurred vision, or weakness. It is very important to call your doctor as soon as you have any of these symptoms, because high blood sugar can cause a serious condition called ketoacidosis. Ketoacidosis may become life-threatening if it is not treated at an early stage. Symptoms of ketoacidosis include dry mouth, nausea and vomiting, shortness of breath, breath that smells fruity, and decreased consciousness.
you should know that paliperidone extended-release injection may cause dizziness, lightheadedness, fast or slow heartbeat, and fainting when you get up too quickly from a lying position, especially right after you receive your injection. If you feel dizzy or drowsy after you receive your injection, you will need to lie down until you feel better. During your treatment, you should get out of bed slowly, resting your feet on the floor for a few minutes before standing up.
you should know that paliperidone extended-release injection may make it harder for your body to cool down when it gets very hot. Tell your doctor if you plan to do vigorous exercise or be exposed to extreme heat. Be sure to drink plenty of water and call your doctor if you experience any of the following symptoms: feeling very hot, sweating heavily, not sweating even though it is hot, dry mouth, excessive thirst, or decreased urination.