Before taking pimozide,
tell your doctor and pharmacist if you are allergic to pimozide, other medications for mental illness, or any other medications.
tell your doctor if you are taking any of the following medications: certain antibiotics including azithromycin (Zithromax, Z-Pak), clarithromycin (Biaxin), erythromycin (E.E.S., E-Mycin, Erythrocin), and moxifloxacin (Avelox); antifungals such as itraconazole (Sporanox) and ketoconazole (Nizoral); arsenic trioxide (Trisenox); dofetilide (Tikosyn); chlorpromazine; dolasetron (Anzemet); droperidol (Inapsine); HIV protease inhibitors such as indinavir (Crixivan), nelfinavir (Viracept), saquinavir (Invirase), and ritonavir (Norvir, in Kaletra); medications for irregular heartbeat such as amiodarone (Cordarone), disopyramide (Norpace), procainamide, quinidine, and sotalol (Betapace); medications for mental illness and nausea; mefloquine (Lariam); nefazadone; pentamidine (Nebu-Pent); certain selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil, Pexeva), and sertraline (Zoloft); tacrolimus (Prograf); thioridazine; zileuton (Zyflo); and ziprasidone (Geodon). Your doctor may tell you not to take pimozide.
tell your doctor if you are taking medications that may cause tics, including amphetamines such as amphetamine (Adderall) and dextroamphetamine (Dexadrine, Dextrostat); pemoline (Cylert) (not available in the US); and methylphenidate (Concerta, Ritalin). Your doctor may tell you to stop taking your medication for a while before you start taking pimozide. This will let your doctor see if your tics were caused by the other medication and can be treated by stopping it.
tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antidepressants; cimetidine (Tagamet); diuretics ('water pills'); medications for anxiety, pain, and seizures; sedatives; sleeping pills; ticlopidine (Ticlid); and tranquilizers. Many other medications may interact with pimozide, so be sure to tell your doctor about all the medications you are taking, even those not listed here or on the lists above. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
tell your doctor if you have or have ever had long QT syndrome (condition that increases the risk of developing an irregular heartbeat that may cause loss of consciousness or sudden death); an irregular heartbeat; or low levels of potassium or magnesium in your blood. Also tell your doctor if you have severe diarrhea before your treatment or at any time during your treatment. Your doctor may tell you not to take pimozide.
tell your doctor if you have or have ever had breast cancer; Parkinson's disease (PD; a disorder of the nervous system that causes difficulties with movement, muscle control, and balance); glaucoma (condition in which increased pressure in the eye can lead to gradual loss of vision); problems with urination; trouble keeping your balance, an abnormal electroencephalogram (EEG; test that records electrical activity in the brain); seizures; or prostate, liver, or kidney disease. Also tell your doctor if you have ever had to stop taking a medication for mental illness due to severe side effects.
tell your doctor if you are pregnant, especially if you are in the last few months of your pregnancy, or if you plan to become pregnant or are breast-feeding. If you become pregnant while taking pimozide, call your doctor. Pimozide may cause problems in newborns following delivery if it is taken during the last months of pregnancy.
if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking pimozide.
you should know that pimozide may make you drowsy and may affect your thinking and movements, especially at the beginning of your treatment. Do not drive a car or operate machinery until you know how this medication affects you.
you should know that pimozide may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.
ask your doctor about the safe use of alcohol during your treatment with pimozide. Alcohol can make the side effects of pimozide worse.