Changes coming to U.S. import regulations, effective August 29th, 2025. All shipments may be affected. Read more for continued updates.
(Bempedoic Acid / Ezetimibe)
Prescription required. Can not be split. Product of UK/EU. Shipped from United Kingdom. Nexlizet is also marketed internationally under the name Nustendi.
Prescription required. Can not be split. Product of India. Shipped from Mauritius.
Nexlizet (Bempedoic Acid / Ezetimibe) is a prescription oral medication used to lower LDL-C (“bad”) cholesterol in adults with primary hyperlipidemia, including heterozygous familial hypercholesterolemia (HeFH). It is often prescribed in combination with statins or other cholesterol-lowering medications for patients who need additional LDL-C reduction or who cannot tolerate statins.
Nexlizet (Bempedoic Acid / Ezetimibe) combines two cholesterol-lowering drugs with distinct mechanisms of action:
Bempedoic acid reduces cholesterol production in the liver
Ezetimibe decreases cholesterol absorption in the intestines
Nexlizet (Bempedoic Acid / Ezetimibe) is not a statin and should be used along with dietary changes and other lipid-lowering therapies when appropriate.
Nexlizet (Bempedoic Acid / Ezetimibe) is prescribed to:
Lower LDL cholesterol in adults with primary hyperlipidemia
Help manage cholesterol in patients with HeFH
Use with or without statins, especially in people who are statin-intolerant
It is not approved for use in children or for the treatment of conditions other than those related to LDL cholesterol reduction.
To comply with Canadian International Pharmacy Association regulations you are permitted to order a 3-month supply or the closest package size available based on your personal prescription. read more
Use Nexlizet exactly as prescribed by your healthcare provider. Common instructions often include:
Take one Nexlizet 180 mg / 10 mg tablet by mouth once daily
Swallow the tablet whole; do not crush, cut, or chew
May be taken with or without food
Take Nexlizet at approximately the same time each day
If you take bile acid-binding medications (e.g., cholestyramine), take Nexlizet at least 2 hours before or 4 hours after those medications
Always check with your provider or pharmacist if you are unsure about how to combine or avoid combining medications.
Before starting Nexlizet (Bempedoic Acid / Ezetimibe), tell your doctor if you:
Have a history of gout or hyperuricemia
Have had tendon problems or are taking medications that increase tendon injury risk (e.g., fluoroquinolones, corticosteroids)
Have kidney or liver problems
Are pregnant, planning to become pregnant, or breastfeeding
Do NOT take Nexlizet (Bempedoic Acid / Ezetimibe) if you:
Are allergic to bempedoic acid, ezetimibe, or any ingredient in the tablet
Nexlizet (Bempedoic Acid / Ezetimibe) is not recommended for children under 18 or for people with severe liver disease or end-stage kidney disease on dialysis.
Continue following a heart-healthy, cholesterol-lowering diet as advised by your doctor
There are no specific food or beverage restrictions, unless otherwise directed
If you miss a dose:
Take it as soon as you remember
If it’s almost time for your next dose, skip the missed dose
Do not take two doses at once
Cold or flu-like symptoms
Muscle pain, back pain, or joint pain
Diarrhea or stomach pain
Fatigue or weakness
Elevated liver enzymes
High uric acid levels (increasing the risk of acute gouty arthritis)
Gout attacks: red, swollen, painful toe or joints
Tendon rupture: sudden pain, swelling, or inability to move a joint (shoulder, biceps, Achilles tendon)
Allergic reactions: rash, itching, swelling of the face/tongue/throat, trouble breathing, dizziness
Liver problems: yellowing of skin or eyes, dark urine, unusual fatigue
Report side effects to your doctor or the FDA at 1-800-FDA-1088.
Store Nexlizet (Bempedoic Acid / Ezetimibe) at room temperature (68–77°F or 20–25°C)
Keep in the original container with the moisture-absorbing packet inside
Protect from heat and moisture
Keep out of reach of children and pets
Do not share Nexlizet (Bempedoic Acid / Ezetimibe) with others
Continue taking other prescribed cholesterol-lowering medications unless told otherwise
Let your provider know about all medications and supplements, especially:
Statins (e.g., simvastatin, pravastatin)
Cyclosporine
Fibrates
Bile acid sequestrants
If overdose is suspected, contact Poison Control at 1-800-222-1222 in the United States or 1-844-764-7669 in Canada.
The content on this page is for informational and educational purposes only and does not constitute professional medical advice. Patients should not use the information presented on this page for diagnosing a health-related issue or disease. Before taking any medication or supplements, patients should always consult a physician or qualified healthcare professional for medical advice or information about whether a drug is safe, appropriate or effective.
