Changes coming to U.S. import regulations, effective August 29th, 2025. All shipments may be affected. Read more for continued updates.
(Budesonide / Glycopyrrolate / Formoterol Fumarate)
Prescription required. Can not be split. Product of New Zealand. Shipped from New Zealand.
Prescription required. Can not be split. Product of India. Shipped from Mauritius.
Breztri Aerosphere (Budesonide/Glycopyrrolate/Formoterol Fumarate) is a prescription inhaler used for the long-term maintenance treatment of chronic obstructive pulmonary disease (COPD) in adults. It contains three medications in a single inhaler: budesonide (a corticosteroid to reduce inflammation), glycopyrrolate (an anticholinergic to relax airway muscles), and formoterol fumarate (a long-acting beta2-agonist that improves breathing). This combination helps reduce symptoms, improve lung function, and decrease flare-ups in people with COPD, including those with chronic bronchitis and/or emphysema.
Breztri Aerosphere (Budesonide/Glycopyrrolate/Formoterol Fumarate) is prescribed to:
Improve lung function and breathing in adults with COPD
Reduce the frequency and severity of COPD exacerbations (flare-ups)
Provide twice-daily maintenance relief from chronic respiratory symptoms
It is not a rescue inhaler and should not be used for sudden breathing problems. Always carry a fast-acting inhaler, such as albuterol, for emergencies.
To comply with Canadian International Pharmacy Association regulations you are permitted to order a 3-month supply or the closest package size available based on your personal prescription. read more
Use Breztri Aerosphere (Budesonide/Glycopyrrolate/Formoterol Fumarate) exactly as prescribed by your healthcare provider. Common instructions often include:
Inhale 2 puffs twice a day—once in the morning and once in the evening
Do not exceed 4 total puffs per day
Rinse your mouth with water and spit it out after each use to help prevent oral thrush (do not swallow)
Do not spray into the eyes. If contact occurs, rinse eyes with water
Always follow the step-by-step instructions provided with your inhaler
Do not stop taking other COPD medications or start new ones without consulting your doctor. Breztri does not replace your rescue inhaler.
Before starting Breztri, inform your doctor if you have:
Heart conditions, high blood pressure, or chest pain
Thyroid, liver, or kidney problems
Diabetes or blood sugar irregularities
Weak bones (osteoporosis)
Eye problems like glaucoma or cataracts
Urinary retention, prostate issues, or bladder problems
Active infections (bacterial, fungal, viral, or parasitic) or a history of pneumonia
A history of severe allergies or are pregnant or breastfeeding
Do NOT use Breztri if you:
Are allergic to budesonide, glycopyrrolate, formoterol, or any other ingredients in the inhaler
Breztri should not be used in children, as it has not been studied in pediatric populations.
No specific dietary changes are needed while using Breztri
If you have diabetes, monitor your blood sugar levels regularly, as Breztri may increase blood glucose
If you miss a dose:
Take it as soon as you remember
If it’s close to the next dose, skip the missed dose
Do not take extra doses to make up for a missed dose
Always use the inhaler at the same time each day to maintain its effectiveness.
Upper respiratory infections
Pneumonia
Oral thrush (rinse and spit after each use to help prevent this)
Back pain
Cough or hoarseness
Sinus inflammation, flu-like symptoms
Diarrhea
Urinary tract symptoms
Fungal infections in the mouth or throat
Sudden breathing problems after inhalation
Pneumonia symptoms: increased cough, mucus, fever, chills
Adrenal insufficiency: weakness, low blood pressure, nausea
Serious allergic reactions: rash, hives, swelling, breathing problems
Eye issues: blurred vision, halos, eye pain, red eyes
Heart issues: rapid heartbeat, chest pain, palpitations
Nervous system effects: tremors, severe anxiety
Urinary retention: weak stream, pain, or difficulty urinating
Call your healthcare provider or the FDA at 1-800-FDA-1088 to report side effects.
Store Breztri at room temperature (68–77°F / 20–25°C)
Keep in its original foil pouch until ready to use
Do not expose to heat or open flame
Do not puncture, incinerate, or store above 120°F (49°C)
Discard the inhaler 3 months after opening (120-dose) or 3 weeks after opening (28-dose), or when the dose counter reads “0”
Keep out of reach of children and pets
Do not share Breztri with others
Breztri is not intended for sudden breathing attacks
Do not use other anticholinergic or LABA medications with Breztri unless directed
Always carry a rescue inhaler (e.g., albuterol)
Tell your provider about all medications and supplements, including:
Other inhalers (e.g., Symbicort, Anoro, Spiriva)
Anticholinergics or LABAs
Antifungals or HIV medications
If overdose is suspected or unusual symptoms occur, call Poison Control at 1-800-222-1222 in the United States or 1-844-764-7669 in Canada, or seek emergency medical care.
The content on this page is for informational and educational purposes only and does not constitute professional medical advice. Patients should not use the information presented on this page for diagnosing a health-related issue or disease. Before taking any medication or supplements, patients should always consult a physician or qualified healthcare professional for medical advice or information about whether a drug is safe, appropriate or effective.
