Before using rectal hydrocortisone,
tell your doctor and pharmacist if you are allergic to hydrocortisone, any other medications, or any of the ingredients in rectal hydrocortisone products. Ask your pharmacist for a list of the ingredients.
tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: amphotericin B (Abelcet, Ambisome, Fungizone); anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); aspirin or other NSAIDs such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); barbiturates; carbamazepine (Carbatrol, Epitol, Tegretol, others); cyclosporine (Gengraf, Neoral, Sandimmune); digoxin (Lanoxin); hormonal contraceptives (birth control pills, patches, rings, implants, and injections); isoniazid (in Rifamate, in Rifater); ketoconazole (Extina, Nizoral, Xolegel); macrolide antibiotics such as clarithromycin (Biaxin, in Prevpac) or erythromycin (E.E.S., Eryc, Eryped, others); medications for diabetes; phenytoin (Dilantin, Phenytek); and rifampin (Rifadin, Rimactane, in Rifamate, in Rifater). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with hydrocortisone, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
tell your doctor if you have a fungal infection (other than on your skin or nails), peritonitis (inflammation of the lining of the stomach area), intestinal obstruction, a fistula (abnormal connection between two organs inside your body or between an organ and the outside of your body) or a tear in the wall of your stomach or intestine. Your doctor may tell you not use rectal hydrocortisone.
tell your doctor if you have or have ever had threadworms (a type of worm that can live inside the body); diabetes; diverticulitis (inflamed bulges in the lining of the large intestine); heart failure; high blood pressure; a recent heart attack; osteoporosis (condition in which the bones become weak and fragile and can break easily); myasthenia gravis (a condition in which the muscles become weak); emotional problems, depression or other types of mental illness; tuberculosis (TB: a type of lung infection); ulcers; cirrhosis; or liver, kidney, or thyroid disease. Also tell your doctor if you have any type of untreated bacterial, parasitic, or viral infection anywhere in your body or a herpes eye infection (a type of infection that causes a sore on the eyelid or eye surface).
tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while using rectal hydrocortisone, call your doctor.
do not have any vaccinations (shots to prevent diseases) without talking to your doctor.
if you are having surgery, including dental surgery, tell the doctor or dentist that you are using rectal hydrocortisone.
you should know that rectal hydrocortisone may decrease your ability to fight infection and may prevent you from developing symptoms if you get an infection. Stay away from people who are sick and wash your hands often while you are using this medication. Be sure to avoid people who have chicken pox or measles. Call your doctor immediately if you think you may have been around someone who had chicken pox or measles.