Linzess® (linaclotide): Uses, Dosage, Side Effects & Warnings (Linaclotide)

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Brand Name

Constella 72mcg Capsule

Prescription required. Can not be split. Product of Canada. Shipped from Canada. Linzess is also marketed internationally under the name Constella.

This item is backorded. May require additional wait time.

$234.99 30 capsules ($7.83/ea)
$437.99 60 capsules ($7.30/ea)
$641.99 90 capsules ($7.13/ea)

Generic equivalent for Linzess

Sorry, we currently do not carry a generic option for this item.

What are generics?

Brand Name

Constella 145mcg Capsule

Prescription required. Can not be split. Product of Canada. Shipped from Canada. Linzess is also marketed internationally under the name Constella.

This item is backorded. May require additional wait time.

$168.99 30 capsules ($5.63/ea)
$315.99 60 capsules ($5.27/ea)
$463.99 90 capsules ($5.16/ea)

Generic equivalent for Linzess

Sorry, we currently do not carry a generic option for this item.

What are generics?

Brand Name

Constella 290mcg Capsule

Prescription required. Can not be split. Product of UK/EU. Shipped from United Kingdom of Great Britain and Northern Ireland. Linzess is also marketed internationally under the name Constella.

$181.99 28 capsules ($6.50/ea)
$324.99 56 capsules ($5.80/ea)
$467.99 84 capsules ($5.57/ea)

Generic equivalent for Linzess

Sorry, we currently do not carry a generic option for this item.

What are generics?

Linzess is a medication that is commonly prescribed for the treatment of various gastrointestinal conditions. Linzess is a medication commonly prescribed for various gastrointestinal conditions. Understanding its uses, dosage, and potential side effects is essential for patients considering this treatment. While Linzess can be effective in managing certain conditions, it is crucial to understand the potential risks and precautions associated with its use. In this discussion, we will explore the uses of Linzess, recommended dosage guidelines, and the potential side effects and warnings that patients should be mindful of. By gaining a comprehensive understanding of this medication, individuals can make informed decisions about their treatment options.

Key Takeaways


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Medication Information

Now let's delve into important medication information about Linzess. We'll discuss the mild side effects that Linzess capsules may cause and explore potential drug interactions. Additionally, we'll address whether Linzess can lead to depression or weight gain/loss. Furthermore, we'll examine whether Linzess is utilized for other digestive conditions, such as opioid-induced constipation, diarrhea, or gastroparesis.

Mild Side Effects

Mild side effects of Linzess include abdominal pain, bloating, gas, and occasional headaches. These side effects are typically manageable and do not necessitate immediate medical attention. It's important to recognize that side effects can vary among individuals, and some may experience different symptoms or varying degrees of severity. If side effects persist or become bothersome, consulting with a healthcare professional for further guidance is advisable. Following the prescribed dosage and any other instructions provided by the healthcare provider is essential to minimize the occurrence of side effects. Overall, while mild side effects may accompany the use of Linzess treatment, they are generally well-tolerated and should not dissuade individuals from seeking treatment for their gastrointestinal conditions.

What Other Drugs Will Affect Linzess?

When considering the medication Linzess, it's essential to be aware of its potential interactions with other drugs. Linzess may interact with certain medications, altering how they work or increasing the risk of side effects. It's crucial to discuss all medications and supplements you're currently taking with your healthcare provider, including prescription, over-the-counter, and herbal products. Drugs that may interact with Linzess include antifungal medications like ketoconazole and itraconazole, certain antibiotics such as erythromycin and clarithromycin, and drugs affecting liver enzymes like rifampin and St. John's wort. Additionally, it's important to avoid taking Linzess with laxatives or other medications that could raise the risk of diarrhea. Always consult your healthcare provider to ensure the safe and effective use of Linzess alongside other medications.

Does Linzess Cause Depression?

Linzess is not known to be associated with causing depression, according to available medication information. Depression is a mood disorder characterized by persistent feelings of sadness, hopelessness, and a lack of interest or pleasure in daily activities. While Linzess is used to treat certain gastrointestinal conditions, it does not directly affect the brain or neurotransmitters associated with depression. It's important to note that everyone's response to medication can vary, and individuals may have different experiences with side effects. If you are concerned about the potential for depression or any other side effects while taking Linzess, it is recommended to consult with your healthcare provider. They can provide personalized advice and guidance based on your specific medical history and needs.

Does Linzess Cause Weight Gain or Weight Loss?

Linzess is not known to have a significant impact on weight gain or weight loss, according to available medication information. This means that taking Linzess is unlikely to cause a noticeable change in your weight. Weight fluctuations can be concerning for individuals taking medication, as they may affect overall well-being and self-image. While Linzess has not been associated with changes in weight overall, individual experiences may vary. If you have concerns about your weight, consulting your doctor will provide an opportunity to develop a personalized plan that addresses all of your needs.

Is Linzess Used for Other Digestive Conditions, Such as Opioid-Induced Constipation, Diarrhea, or Gastroparesis?

Although Linzess is primarily used for the treatment of a specific digestive condition, it may also be prescribed for other gastrointestinal disorders, such as opioid-induced constipation, diarrhea, or gastroparesis, at a healthcare provider's discretion. Opioid-induced constipation is a common side effect of using opioid medications for pain management. Linzess can help relieve this type of chronic constipation by increasing the movement of the bowels.

Diarrhea is considered a side effect of Linzess. The medication is used to treat chronic constipation and is not typically prescribed to help manage existing diarrhea. Existing diarrhea may be made worse by using Linzess.

Gastroparesis, a condition where the stomach takes longer than usual to empty its contents, can also be managed with Linzess. This medication works by enhancing the contractions of the muscles in the digestive system, aiding in the movement of food through the stomach. If you are experiencing any of these digestive conditions, consult your healthcare provider to determine if Linzess is an appropriate treatment option for you.

Prescription and Treatment

When it comes to the prescription and treatment of Linzess, there are a few important points to consider. One of these is whether the side effects vary depending on the strength of the medication (72 mcg, 145 mcg, or 290 mcg). Additionally, it is important to know what happens if a dose is missed and how to administer Linzess with water via a nasogastric or gastrostomy tube. Other considerations include the use of Linzess in children and the specific details of its side effects.

Do Side Effects of Linzess Vary Depending on the Strength (72 mcg, 145 mcg, or 290 mcg)?

The potential side effects of Linzess may vary depending on the strength of the medication prescribed, whether it is 72 mcg, 145 mcg, or 290 mcg. It is important to note that the most common side effects of Linzess include diarrhea, abdominal pain, gas, and bloating. These side effects are generally mild and may occur with all strengths of the medication. However, the severity and frequency of these side effects may differ depending on the individual and the dosage prescribed. It is always recommended to consult with a healthcare professional for personalized advice and guidance regarding the potential side effects of Linzess and the appropriate dosage for your specific condition.

What Happens if I Miss a Dose?

If you forget to take a dose, take it as soon as you remember unless it is close to your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. It is important to follow the prescribed dosing schedule to ensure the effectiveness of the medication. If you have any questions or concerns about missed doses or the proper administration of Linzess, it is recommended that you consult your healthcare provider or pharmacist for guidance. They can provide you with the necessary information and support to ensure you are taking the medication correctly.

Administration With Water Via A Nasogastric Or Gastrostomy Tube

Administering Linzess in water via a nasogastric or gastrostomy tube is an effective method, and healthcare professionals may recommend using it in this way. It is important to ensure that the medication is properly dissolved in water before administration. The recommended dose of Linzess should be mixed with 30 milliliters of water and stirred until fully dissolved. The mixture should then be administered through the nasogastric or gastrostomy tube using a syringe or other appropriate device. After administration, the tube should be flushed with additional water to ensure that the full dose of medication has been delivered. It is crucial for healthcare professionals to closely monitor patients during and after administration to ensure proper absorption and address any potential complications.

Linzess Use In Children

Linzess is prescribed to address specific medical conditions in children and has been approved for managing functional constipation (FC) in children aged 6 to 17 years. However, it's essential to recognize that the safety and effectiveness of Linzess in children under 6 years of age have not been established. Of particular concern is its safety in children under 2 years old due to the potential for diarrhea and subsequent dehydration.

When prescribing Linzess for children, healthcare professionals consider factors such as the child's age, weight, and overall health. The dosage is determined based on these factors, and strict adherence to the prescribed dosage and administration instructions is crucial. Like any medication, children may experience side effects while taking Linzess. Consulting the child's doctor for more information on potential side effects and addressing any concerns or questions is essential.

Linzess Side Effects

The potential side effects of Linzess in children should be carefully considered and discussed with a healthcare professional. Common side effects of Linzess include diarrhea, abdominal pain, gas, and bloating. It's important to note that side effects may vary depending on the condition being treated.

While serious side effects are less common, they may include severe stomach pain, persistent diarrhea, and allergic reactions that require immediate medical attention. Although allergic reactions have not been reported in studies, it's crucial to seek medical advice if any serious side effects occur. Additionally, consulting a child's doctor for information about specific side effects in children is essential, as they may differ from those experienced by adults.

Drug Details

Now let's delve into the details of Linzess as a drug. This will include a discussion of the clinical trial experience, adverse reactions leading to dose reductions, and the overall risk summary associated with the medication. Understanding these aspects is crucial to gaining a comprehensive understanding of the drug and its potential effects.

Clinical Trials Experience

During clinical trials, the experiences of patients treated with Linzess were carefully monitored to assess its efficacy and safety in treating the targeted conditions. The trials involved a large number of participants who were closely monitored for any adverse effects or complications. The results of these trials showed that Linzess was effective in relieving symptoms such as diarrhea and abdominal pain associated with certain gastrointestinal conditions. The trials also demonstrated that the medication was generally well-tolerated, with the most common side effects being diarrhea, abdominal pain, gas, and bloating. Serious side effects were rare, but immediate medical attention was recommended if severe diarrhea or an allergic reaction occurred. Overall, the clinical trials provided valuable insights into the effectiveness and safety of Linzess in treating the targeted conditions.

Adverse Reactions Leading to Dose Reductions

During clinical trials assessing the efficacy and safety of Linzess, specific adverse reactions were noted, resulting in dose reductions for some participants. These adverse reactions included diarrhea, severe abdominal pain, and bloating. When these side effects were severe or persistent, the dose of Linzess was often reduced to minimize their impact. It is important for healthcare professionals to closely monitor patients taking Linzess for any signs of adverse reactions and to adjust the dosage accordingly. By reducing the dose, the aim is to alleviate the symptoms while maintaining the medication's therapeutic benefits. Patients should communicate any bothersome or concerning side effects to their healthcare provider, who can then make appropriate adjustments to the Linzess dose to optimize patient comfort and well-being.

Risk Summary

Evaluating the risks of therapy and weighing them against the potential benefits is central to deciding whether to start any new medication. It is crucial to be aware of these risks in order to make informed decisions about the use of Linzess.

The common side effects of Linzess are frequently mild, however, there are precautions to be aware of. These include the potential for:

  • Severe diarrhea leading to dehydration requiring emergency care.

  • Concerns related to breastfeeding, which are best discussed on an individual basis.

  • Concerns related to pregnancy and a lack of safety data related to human fetal development.

Interactions with Other Medications

Linzess may interact with other medications, potentially leading to adverse effects or reduced effectiveness. Make sure your doctor is aware of all prescription, over-the-counter, and herbal supplements you are currently taking. This will help your doctor assess the risk of any potential drug interactions.

One important consideration is the impact of Linzess on medications used to manage type 2 diabetes. Linzess can affect the absorption of these medications, potentially causing fluctuations in blood sugar levels. Therefore, it is recommended to closely monitor blood sugar levels when using Linzess alongside antidiabetic agents.

Additionally, certain antibiotics, antifungal medications, and drugs used to treat HIV/AIDS may interact with Linzess. These medications can alter the levels of Linzess in the body, leading to either decreased effectiveness or an increased risk of side effects.

It's worth noting that this list is not exhaustive, and there may be other medications that can interact with Linzess. Always consult your healthcare provider or pharmacist for a comprehensive list of potential drug interactions before starting Linzess or any new medication. They can offer personalized advice based on your specific medical history and current medication regimen to ensure your safety and well-being.

Additional Information

While Linzess is generally well-tolerated, it's important to be aware of some nuances related to side effects. During clinical trials with adults, aside from gastrointestinal side effects, slightly increased incidences of upper respiratory tract infections (e.g., colds and flu) and sinusitis (inflamed sinuses or sinus infections) were observed.

In trials with children, a lower overall rate of diarrhea was observed, but some patients discontinued treatment due to severe diarrhea. Additionally, nausea was reported in a small number of patients.

Before starting Linzess, it's essential to discuss any concerns about alcohol consumption, pregnancy, or breastfeeding with your healthcare provider.

Frequently Asked Questions

Can Linzess Cause Weight Gain or Weight Loss?

Linzess has not been associated with weight gain or weight loss. It is important to consult with a healthcare professional for personalized information and guidance regarding the effects of Linzess on weight management.

How Long Do the Side Effects of Linzess Typically Last?

The duration of side effects from Linzess can vary for each individual. If your symptoms persist or become worse, contact your healthcare professional.

Is Fatigue a Common Side Effect of Linzess?

Fatigue is not a common side effect of Linzess. However, it can cause diarrhea, and it left untreated, this can lead to dehydration. Fatigue can be associated with dehydration. If you are experiencing diarrhea and fatigue, contact your healthcare provider.

Can the Side Effects of Linzess Vary Depending on the Strength of the Medication?

Yes, the side effects of Linzess can vary depending on the strength of the medication. It is important to consult with your doctor to understand the potential side effects associated with the specific dosage of Linzess prescribed to you.

Does Linzess Cause Hair Loss as a Side Effect?

Linzess has not been associated with hair loss. It is important to consult with a healthcare professional for any concerns regarding hair loss or other potential issues.


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The content on this page is for informational and educational purposes only and does not constitute professional medical advice. Patients should not use the information presented on this page for diagnosing a health-related issue or disease. Before taking any medication or supplements, patients should always consult a physician or qualified healthcare professional for medical advice or information about whether a drug is safe, appropriate or effective.