Before using brimonidine eye drops,
tell your doctor or pharmacist if you are allergic to brimonidine eye drops or any other medications.
do not use brimonidine eye drops if you are taking a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl), or tranylcypromine (Parnate).
tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antidepressants such as amitriptyline (Elavil), amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Adapin, Sinequan), imipramine (Tofranil), nortriptyline (Aventyl, Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil); barbiturates such as phenobarbital and secobarbital (Seconal); digoxin (Lanoxin); medications for anxiety, high blood pressure, mental illness, pain, or seizures; sedatives; sleeping pills; and tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
if you are using any other topical eye medications, instill them 5 minutes before or 5 minutes after you instill brimonidine eye drops.
tell your doctor if you often feel dizzy when you sit or stand from a lying position and if you have or have ever had depression; conditions that affect your blood circulation including Raynaud's disease (a condition that causes attacks of low blood circulation to the fingers and toes), thromboangiitis obliterans (a condition that causes poor blood circulation in the hands and feet), and problems with blood flow to your heart or brain; or heart, kidney, or liver disease.
tell your doctor if you are pregnant or plan to become pregnant. If you become pregnant while you are using brimonidine eye drops, call your doctor. Do not breast-feed while you are using brimonidine eye drops.
if you are having surgery, including dental surgery, tell your doctor or dentist that you are using brimonidine eye drops.
you should know that brimonidine eye drops may make you drowsy. Your vision may be blurry for a few minutes after you instill the eye drops. Do not drive a car or operate machinery until you know how this medication affects you.
ask your doctor about the safe use of alcohol while you are using brimonidine eye drops. Alcohol can make the drowsiness caused by brimonidine eye drops worse.
tell your doctor if you wear soft contact lenses. Remove your soft contact lenses before instilling brimonidine eye drops and wait at least 15 minutes after using the medication to replace your lenses.