Before taking teriflunomide,
tell your doctor and pharmacist if you are allergic to teriflunomide (rash, hives, shortness of breath, swelling of the face, eyes, mouth, throat, tongue, lips, hands, feet, ankles, or lower legs), leflunomide (Arava), any other medications, or any of the ingredients in teriflunomide tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
tell your doctor if you are taking leflunomide (Arava). Your doctor will probably tell you not to take teriflunomide if you are taking this medication.
tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: alosetron (Lotronex); anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); atorvastatin (Lipitor, in Caduet); cefaclor; cimetidine (Tagamet); ciprofloxacin (Cipro); duloxetine (Cymbalta); eltrombopag (Promacta); furosemide (Lasix); gefitinib (Iressa); ketoprofen; medications that can cause nerve damage such as medications for cancer, HIV, or AIDS; other medications that suppress the immune system such as azathioprine (Azasan, Imuran), cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), and tacrolimus (Astagraf, Envarsus XR, Prograf); methotrexate (Otrexup, Rasuvo, Trexall); mitoxantrone; nateglinide (Starlix); oral contraceptives (birth control pills); paclitaxel (Abraxane, Taxol); penicillin G; pioglitazone (Actos, in Actoplus Met, in Duetact); pravastatin (Pravachol); repaglinide (Prandin, in Prandimet); rifampin (Rifadin, Rimactane, in Rifamate, in Rifater); rosiglitazone (Avandia); rosuvastatin (Crestor); simvastatin (Zocor, in Vytorin); theophylline (Elixophyllin, Theo-24, Uniphyl, others); tizanidine (Zanaflex); and zidovudine (Retrovir, in Combivir, in Trizivir). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with teriflunomide, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
tell your doctor if you have an infection now, including an ongoing infection that does not go away, or if you have or have ever had a serious skin reaction after you took another medication; diabetes; breathing problems; cancer or other conditions affecting the bone marrow or the immune system; high blood pressure; peripheral neuropathy (numbness, burning or tingling in the hands or feet that feels different from your MS symptoms); or kidney disease.
tell your doctor if you are breast-feeding.
if your partner plans to become pregnant, you should talk to your doctor about stopping teriflunomide and receiving a treatment to help remove this medication from your body more quickly. If your partner does not plan to become pregnant, you and your partner should use an effective method of birth control during your treatment with teriflunomide and for up to 2 years after treatment, until blood tests show that you have low enough levels of teriflunomide in your blood.
if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking teriflunomide.
you may already be infected with tuberculosis (TB; a serious lung infection) but not have any symptoms of the disease. Tell your doctor if you have or have ever had TB, if you have lived in or visited a country where TB is common, or if you have been around someone who has or has ever had TB. Before you begin your treatment with teriflunomide, your doctor will perform a skin test to see if you have TB. If you do have TB, your doctor will treat this infection before you begin taking teriflunomide.
do not have any vaccinations without talking to your doctor while you are taking teriflunomide and for 6 months after you stop taking it.
you should know that teriflunomide may cause high blood pressure. You should have your blood pressure checked before starting treatment and regularly while you are taking this medication.