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(Rifaximin)
Prescription required. Can not be split. Product of UK/EU. Shipped from United Kingdom. Xifaxan is also marketed internationally under the name Xifaxanta.
Prescription required. May be split. Product of India. Shipped from Mauritius.
This item is backorded. May require additional wait time.
Prescription required. May be split. Product of India. Shipped from Mauritius.
This item is backorded. May require additional wait time.
Prescription required. Can not be split. Product of Italy. Shipped from Australia.
Prescription required. Can not be split. Product of UK/EU. Shipped from United Kingdom.
Xifaxan is a non-absorbable antibiotic that acts locally in the intestines to fight specific bacterial infections. Unlike many antibiotics, it passes through the digestive tract without entering the bloodstream, making it ideal for gastrointestinal conditions. It is not effective for infections in other areas of the body.
Xifaxan is commonly used for:
Traveler’s Diarrhea: Caused by Escherichia coli (E. coli) in adults and children ≥12 years.
Irritable Bowel Syndrome with Diarrhea (IBS-D): For adults experiencing chronic diarrhea-predominant IBS.
Hepatic Encephalopathy: To reduce the recurrence of brain function decline due to liver failure by reducing levels of toxin-producing bacteria in the gut.
It may also be prescribed for other conditions as determined by your healthcare provider.
To comply with Canadian International Pharmacy Association regulations you are permitted to order a 3-month supply or the closest package size available based on your personal prescription. read more
Dosage information and scheduling should be provided by the prescribing healthcare provider. While your individual recommendation may vary, many dosing schedules are similar to those recommended by the manufacturer:
For IBS-D: 550 mg taken three times a day for 14 days. If symptoms return, this regimen may be used again.
For Traveler’s Diarrhea: 200 mg taken three times a day for 3 days.
For Hepatic Encephalopathy: 550 mg taken twice a day. Daily use is recommended long-term for the prevention of symptoms.
Condition | Dosage | Duration |
Irritable Bowel Syndrome | 550 mg, 3 times/day | 14 days |
Traveler’s Diarrhea | 200 mg, 3 times/day | 3 days |
Hepatic Encephalopathy | 550 mg, twice/day | Long-term use |
Take Xifaxan exactly as prescribed. Follow your doctor’s instructions and read all medication guides.
With or without food.
Do not stop early—even if symptoms improve—complete the full course. This helps ensure infections do not return and helps prevent antibiotic resistance.
Traveler’s Diarrhea: 200 mg 3×/day for 3 days
Hepatic Encephalopathy: 550 mg 2×/day
IBS-D: 550 mg 3×/day for 14 days (can be repeated up to 2 times if symptoms return)
Do NOT use Xifaxan if you:
Are allergic to rifaximin, rifampin, rifabutin, or rifapentine
Tell your doctor if you have:
Liver disease (additional caution is needed in individuals managing severe liver disease)
Diarrhea with fever, or watery/bloody stools
A positive pregnancy test or are breastfeeding
Children under 12 should not use Xifaxan.
There are no specific food restrictions, and Xifaxan may be taken with or without meals.
Avoid anti-diarrheal medications unless directed by a healthcare provider, especially if diarrhea is watery or bloody.
Take the missed dose as soon as you remember.
If it’s almost time for the next dose, skip the missed one—do not double up.
Contact your doctor if unsure how to proceed.
Common Side Effects:
Many of the symptoms reported by individuals taking Xifaxan are also commonly experienced when managing the the conditions being treated. If any symptoms persist or worsen rather than improve, contact your healthcare provider.
Swelling of hands or feet
Nausea
Dizziness
Fatigue
Abdominal swelling
Skin rash
Abdominal pain
Anemia
Serious Side Effects (seek immediate help):
Allergic reactions: hives, swelling of face/lips/throat, breathing trouble
Severe stomach pain or bloody diarrhea
Fever
Rapid weight gain, bloating, or trouble breathing (sometimes due to fluid buildup in the abdomen)
Report side effects to the FDA at 1-800-FDA-1088.
Store at room temperature (68°F to 77°F or 20°C to 25°C)
Keep away from moisture and heat
Do not freeze
Keep out of reach of children
Do not share Xifaxan with others, even if symptoms are similar.
Xifaxan does not treat viral infections such as colds or flu.
Call your doctor if symptoms don’t improve within 24–48 hours or worsen.
Possible drug interactions include:
Cyclosporine, ketoconazole, warfarin
Antibiotics (clarithromycin, erythromycin)
Antivirals (ritonavir, saquinavir)
Heart medications (amiodarone, quinidine, verapamil)
Always provide your doctor with a complete list of medications, supplements, and herbs you’re using.
Rifaximin (ri fax' I men) Xifaxan®
Rifaximin 200-mg tablets are used to treat traveler's diarrhea caused by certain bacteria in adults and children at least 12 years of age. Rifaximin 550-mg tablets are used to prevent episodes of hepatic encephalopathy (changes in thinking, behavior, and personality caused by a build-up of toxins in the brain in people who have liver disease) in adults who have liver disease and to treat irritable bowel syndrome (with diarrhea) in adults. Rifaximin is in a class of medications called antibiotics. Rifaximin treats traveler's diarrhea and irritable bowel syndrome by stopping the growth of the bacteria that cause diarrhea. Rifaximin treats hepatic encephalopathy by stopping the growth of bacteria that produce toxins and that may worsen liver disease. Rifaximin will not work to treat traveler's diarrhea that is bloody or occurs with fever. Antibiotics such as rifaximin will not work for colds, flu, or other viral infections. Taking antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.
Rifaximin comes as a tablet to take by mouth with or without food. When rifaximin is used to treat traveler's diarrhea, it is usually taken three times a day for 3 days. When rifaximin is used to prevent episodes of hepatic encephalopathy, it is usually taken twice a day. When rifaximin is used to treat irritable bowel syndrome, it is usually taken three times a day for 14 days. To help you remember to take rifaximin, take it around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take rifaximin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. If you are taking rifaximin to treat traveler's diarrhea, your symptoms should improve within 24 to 48 hours after you start taking the medication. If your symptoms do not go away or they get worse, or if you develop a fever or bloody diarrhea, call your doctor. If you are taking rifamaxin to treat irritable bowel syndrome and your symptoms return after you have finished your treatment, call your doctor. Take rifaximin as directed, even if you feel better. If you are taking rifaximin to treat traveler's diarrhea or irritable bowel syndrome and you stop taking it too soon or if you skip doses, your infection may not be completely cured and the bacteria may become resistant to antibiotics. If you are taking rifaximin to prevent hepatic encephalopathy, do not stop taking it without talking to your doctor as you may experience symptoms of encephalopathy.
Before taking rifaximin, tell your doctor and pharmacist if you are allergic to rifaximin, rifabutin (Mycobutin), rifampin (Rifadin, Rifamate, Rifater, Rimactane), rifapentine (Priftin), any other medications, or any of the ingredients in rifaximin capsules. Ask your doctor or pharmacist for a list of the ingredients. tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or have recently taken. Be sure to mention cyclosporine (Gengraf, Neoral, Restasis, Sandimmune) or other antibiotics. Your doctor may have to change the doses of your medications, monitor you carefully for side effects or treat your diarrhea differently. tell your doctor if you have or have ever had liver disease. tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking rifaximin, call your doctor.
Unless your doctor tells you otherwise, continue your normal diet.
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Rifaximin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: nausea stomach pain dizziness excessive tiredness headache muscle tightening joint pain Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately: watery or bloody diarrhea that may occur along with stomach cramps and fever during your treatment or for 2 months afterward hives rash itching difficulty breathing or swallowing swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs hoarseness Rifaximin may cause other side effects. Call your doctor if you have any unusual problems while taking this medication. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program. It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org
Keep all appointments with your doctor. Do not let anyone else take your medication. Ask your pharmacist if you have any questions about refilling your prescription. It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
The content on this page is for informational and educational purposes only and does not constitute professional medical advice. Patients should not use the information presented on this page for diagnosing a health-related issue or disease. Before taking any medication or supplements, patients should always consult a physician or qualified healthcare professional for medical advice or information about whether a drug is safe, appropriate or effective.
