Zydelig (Idelalisib)

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Idelalisib Information

IDELALISIB (eye del AL isib) is a chemotherapy drug. It targets proteins in cancer cells and stops the cancer cells from growing.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

They need to know if you have any of these conditions: -infection -inflammatory bowel disease -liver disease -low blood count, like low white cell, platelet, or red cell counts -lung or breathing disease, like asthma -stomach or intestine problems -an unusual or allergic reaction to idelalisib, other medicines, foods, dyes, or preservative -pregnant, or trying to get pregnant -breast-feeding

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Do not cut, crush or chew this medicine. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice. Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Do not take this medicine with any of the following medications: -atorvastatin -carbamazepine -cerivastatin -cisapride -dasatinib -dihydroergotamine -doxorubicin -dronedarone -eletriptan -enzalutamide -ergotamine -fosphenytoin -halofantrine -ketoconazole -lovastatin -midazolam -nefazodone -nelfinavir -nifedipine -phenobarbital -phenytoin -pimozide -primidone -propafenone -quetiapine -quinidine -ranolazine -rifabutin -rifampin -rilpivirine -risperidone -ritonavir -sildosin -simvastatin -sirolimus -St. John's Wort, Hypericum perforatum -vinblastine -ziprasidone This medicine may also interact with the following medications: -certain medicines for blood pressure, heart disease, irregular heart beat -certain medicines for blood pressure like amlodipine, felodipine, nifedipine -certain medicines for cholesterol like atorvastatin, lovastatin, and simvastatin -certain medicines for depression, anxiety, or psychotic disturbances -certain medicines for erectile dysfunction -certain medicines that treat or prevent blood clots like warfarin, enoxaparin, dalteparin, apixaban, dabigatran, and rivaroxaban -ergot alkaloids like dihydroergotamine, ergotamine -narcotic medicines for pain

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop. Men and women should use effective birth control while taking this medicine. Do not become pregnant while taking this medicine. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine. This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding. If you are going to have surgery or any other procedures, tell your doctor you are taking this medicine. Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick. You may need blood work done while you are taking this medicine.

Side effects that you should report to your doctor or health care professional as soon as possible: -allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue -breathing problems -diarrhea -low blood counts - this medicine may decrease the number of white blood cells, red blood cells and platelets. You may be at increased risk for infections and bleeding -nausea, vomiting -redness, blistering, peeling or loosening of the skin, including inside the mouth -signs and symptoms of bleeding such as bloody or black, tarry stools; red or dark-brown urine; spitting up blood or brown material that looks like coffee grounds; red spots on the skin; unusual bruising or bleeding from the eye, gums, or nose -signs of infection - fever or chills, cough, sore throat, pain or difficulty passing urine -signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like symptoms; light-colored stools; loss of appetite; nausea; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin -stomach pain Side effects that usually do not require medical attention (Report these to your doctor or health care professional if they continue or are bothersome.): -cough -headache -signs and symptoms of high blood sugar such as dizziness; dry mouth; dry skin; fruity breath; nausea; stomach pain; increased hunger or thirst; increased urination -signs and symptoms of low blood sugar such as feeling anxious; confusion; dizziness; increased hunger; unusually weak or tired; sweating; shakiness; cold; irritable; headache; blurred vision; fast heartbeat; loss of consciousness -weak or tired

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Keep out of the reach of children. Store between 20 and 30 degrees C (68 and 86 degrees F). Keep this medicine in the original container. Throw away any unused medicine after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Idelalisib Oral tablet