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(eye del'' a lis' ib)Idelalisib may cause serious or life threatening liver damage. Tell your doctor if you have or ever have had liver disease. The risk of liver damage may be increased in people taking other medications known to cause liver damage, and in people who already have liver disease. Tell your doctor and pharmacist about the medications you are taking so they can check whether any of your medications may increase the risk that you will develop liver damage during your treatment with idelalisib. If you experience any of the following symptoms, call your doctor immediately: extreme tiredness, loss of appetite, weight loss, nausea, vomiting, unusual bleeding or bruising, yellowing of the skin or eyes, dark yellow or brown-colored urine, pale stools, or pain in the upper right part of the stomach. Idelalisib may cause diarrhea, colitis (swelling of the large intestine), or holes in the stomach or intestine. Tell your doctor if you have diarrhea or if you have ever had colitis or other conditions that affect your stomach or intestine. The risk of diarrhea may be increased in people taking other medications known to cause diarrhea. Tell your doctor and pharmacist about the medications you are taking so they can check whether any of your medications may increase the risk that you will develop diarrhea during your treatment with idelalisib.If you experience any of the following symptoms, call your doctor immediately: if your number of bowel movements in a day increases by 6 or more , stomach cramps or pain, chills, fever, nausea, or vomiting. Idelalisib may cause serious or life threatening pneumonitis (swelling of the lungs). Tell your doctor if you have lung disease or breathing problems. If you experience any of the following symptoms, call your doctor immediately: new or worsening cough, difficulty breathing, wheezing, or shortness of breath. Idelalisib may cause serious or life threatening infections. Tell your doctor if you have an infection, or if you have or have ever had cytomegalovirus (CMV; a viral infection that may cause symptoms in patients with weak immune systems). If you experience any of the following symptoms, call your doctor immediately: fever, sore throat, chills, painful, frequent, or difficult urination, or other signs of infection. Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to idelalisib. Talk to your doctor about the risks of taking idelalisib.
Before taking idelalisib,
- tell your doctor and pharmacist if you are allergic to idelalisib, any other medications, or any of the ingredients in idelalisib tablets. If you have ever had a severe allergic reaction in the past, such as swelling of your face, lips or throat; difficulty swallowing or breathing; or peeling, blistering skin, your doctor will probably tell you not to take idelalisib.Ask your pharmacist or check the Medication Guide for a list of the ingredients.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: carbamazepine (Carbatrol, Epitol, Equetro, others); clarithromycin (Biaxin, in PrevPac); itraconazole (Onmel, Sporanox); ketoconazole (Nizoral); medications used to treat human immunodeficiency virus (HIV) such as efavirenz (Sustiva, in Atripla), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, in Kaletra, in Technivie); midazolam; nefazodone; phenobarbital; phenytoin (Dilantin, Phenytek); pioglitazone (Actos, in Actoplus Met, in Duetact, in Oseni); rifabutin (Mycobutin); and rifampin (Rifadin, Rimactane, in Rifamate, in Rifater). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with idelalisib, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
- tell your doctor and pharmacist what herbal products you are taking, especially St. John's wort. You should not take St. John's wort during your treatment with idelalisib.
- tell your doctor if you are pregnant, plan to become pregnant, or plan to father a child. You should not become pregnant during your treatment with idelalisib. You should use birth control to prevent pregnancy during your treatment with idelalisib and at least 1 month after your final dose. If you are a male and your partner can become pregnant, you should use effective birth control during your treatment and for 3 months after your final dose. If you or your partner become pregnant while taking idelalisib, call your doctor immediately. Idelalisib may harm the fetus.
- tell your doctor if you are breastfeeding. You should not breastfeed while you are taking idelalisib and for at least one month after your final dose.
- difficulty falling asleep or staying asleep
- decreased appetite
- increased thirst
- joint pain
- night sweats
- lack of energy
- swelling of the hands, feet, ankles, or lower legs
- red, itching, peeling, or blistering skin
- painful sores or ulcers on your skin, lips, or in your mouth
- difficulty swallowing or breathing; swelling of the face, lips, or throat; hives; itching