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Entresto (Sacubitril / Valsartan) is a prescription oral medication used to treat chronic heart failure in adults and certain children over one year old. It combines two active ingredients—sacubitril and valsartan—that work together to improve heart function and reduce the risk of hospitalization and death. Sacubitril enhances the effects of natural peptides that relax blood vessels and promote sodium excretion, while valsartan blocks the effects of angiotensin II, a hormone that narrows blood vessels.

Entresto is especially beneficial for adults with reduced ejection fraction (HFrEF), meaning the heart doesn't pump blood effectively. It carries risks of low blood pressure, kidney issues, high potassium, and rare but serious allergic reactions like angioedema. It should not be used during pregnancy or alongside ACE inhibitors.

Key Takeaways

Online Pharmacies Offer the Best Cash Prices: Planet Drugs Direct and DrugMart offer Entresto for $139–$166 per 30 tablets—over 75% cheaper than U.S. retail prices, which typically range from $709 to $738 at major chains like CVS, Walgreens, and Walmart.
$10 Copay Program for Private Insurance: Eligible patients with commercial insurance can use the Novartis copay card to get a 30 to 90-day supply for just $10, saving thousands annually—up to $4,100 in manufacturer support per year.
Medicare Part D Lowers Monthly Cost to Under $50: With preferred formulary placement on 95% of Medicare Part D plans, most beneficiaries pay less than $50 per month, and some may even qualify for a free 30-day trial supply.

Cheapest Online Pharmacies for Entresto (Sacubitril / Valsartan)

Here are the cheapest online pharmacies where you can purchase Entreso (Sacubitril / Valsartan) and get it shipped safely, right to your door.

Pharmacy	Prescription Required	Price Per 30 Tablets	Milligram	Website
Planet Drugs Direct	Yes	$139.64	97.2/102.8 mg	Visit
DrugMart	Yes	$166.82	97.2/102.8 mg	Visit
Amazon Pharmacy	Yes	$359.83	97.2/102.8 mg	Visit

Prices as of April 30, 2025. Prices are subject to change based on quantity, milligram, and other details regarding your prescription needs.

U.S. Pharmacies and Entresto Average Prices

The most common US pharmacies that carry Entrsto (Sacubitril / Valsartan) are Jewel-Osco, Walgreens, CVS Pharmacy, and Walmart. On average, prices can range anywhere from $708.68 on the low side to $738.02 on the higher side.

As of April 2025, common monthly prices of a 30 to 90 tablets include:

Jewel-Osco: $709.68
Walgreens: $731.35
CVS Pharmacy: $737.60
Walmart: $738.02

How to Save on Entresto (Sacubitril / Valsartan)

Here are some ways to save on Entresto (Sacubitril / Valsartan):

1. Get the $10 Entresto Copay Card if You Have Private Insurance

If you're covered under commercial or employer-sponsored insurance, Novartis offers a copay savings card that reduces your cost to as little as $10 for a 30, 60, or 90-day supply. The program covers up to $4,100 per calendar year and renews automatically.

Just present the card at a participating pharmacy when you fill your prescription.

2. Use Medicare Part D’s Preferred Coverage for Entresto

Entresto has preferred status on over 95% of Medicare Part D plans, and 99% of patients can access it at the lowest brand-name copay, often less than $50. This means if you're on Medicare, you're likely already getting one of the best rates available.

Use the “Check My Medicare Coverage” tool to help determine if you’re eligible.

3. Start with a Free 30-Day Trial if You’re New to Entresto and on Medicare

If you're beginning Entresto and covered by Medicare Part D, you may be eligible for a free 30-day trial (up to 60 tablets) through a manufacturer-sponsored program. This allows you to test the medication without financial commitment before regular copays apply.

4. Call Your Insurer and Confirm Your Plan Accepts the Copay Program

Whether you’re on commercial insurance or Medicare, always call your prescription insurance provider to confirm two things:

That Entresto is covered under your plan
That your pharmacy accepts the $10 copay card (for private insurance users)

This helps avoid surprises and ensures you're maximizing your savings options.

5. Consider Online Pharmacies

Online pharmacies like Planet Drugs Direct and DrugMart both offer Entresto for up to 80% off the typical prescription. Both of these pharmacies are considered CIPA-certified international pharmacies that ship directly to the US.

Ready to save up to 80% off your medication? Visit our page on Planet Drugs Direct.

Common Questions

Common questions and answers about Entresto:

1. Is Entresto covered by Medicare?

Yes, Entresto is covered by Medicare Part D and has preferred coverage on more than 95% of Part D plans. That means it is widely accessible to Medicare beneficiaries and is usually placed on a lower-cost formulary tier by most insurers.

2. How much would I expect to pay if I have Medicare coverage?

Most people with Medicare Part D pay less than $50 per prescription fill for Entresto. The exact amount depends on your specific plan and whether you've reached your deductible or coverage gap.

3. How long am I required to be on my prescription and how much would that cost?

Entresto is prescribed as a long-term medication for managing chronic heart failure, often taken indefinitely to reduce the risk of hospitalization and death. Without Medicare Part D or any insurance, the out-of-pocket cost can be high, typically ranging from $600 to over $1,200 per month, depending on the pharmacy and dosage. That could total $7,000 to $14,000 per year if no discounts or assistance programs are used.

Rely on PlanetDrugsDirect.com to Buy Online Entresto (Sacubitril / Valsartan)

As a trusted prescription referral service, we offer important benefits whenever you order online. Each of our partner pharmacies and/or government-approved dispensaries is committed to providing the best experience possible of any online prescription referral service on the internet. We offer:

Low prices
Quick turn-around times
Generic and brand-name medications
Unparalleled customer service

Sources

Centers for Medicare & Medicaid Services. (n.d.). What's Medicare Drug Coverage (Part D)?. Medicare.gov. Retrieved April 30, 2025, from https://www.medicare.gov/health-drug-plans/part-d
Novartis Pharmaceuticals Corporation. (2021, February). Entresto (sacubitril and valsartan) tablets, for oral use: Prescribing information. U.S. Food and Drug Administration. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/207620s018lbl.pdf