Medically reviewed by 
Xifaxan (Rifaximin) is a prescription oral antibiotic used to treat irritable bowel syndrome with diarrhea (IBS-D), hepatic encephalopathy, and traveler’s diarrhea caused by E. coli. Unlike broad-spectrum antibiotics, Xifaxan stays largely in the gut, making it ideal for targeting gastrointestinal bacterial overgrowth without significant systemic absorption.
Xifaxan is typically prescribed as a 550mg tablet taken two to three times daily, depending on the condition being treated. However, the medication is extremely expensive without insurance, with U.S. retail prices often exceeding $5,000 per month. Fortunately, patients can save significantly through manufacturer savings programs and international pharmacies.
Key Takeaways
U.S. Retail Pharmacies Charge $1,600–$1,800+ for a 30-Day Supply: As of April 2025, a 30-day fill of Xifaxan 550mg costs between $1,582 and $1,803 at major U.S. chains like Walgreens, Walmart, Target, and Meijer—making it one of the most expensive GI medications without insurance.
CIPA-Certified Pharmacies Offer Xifaxan for Under $500/Month: International online pharmacies such as Planet Drugs Direct and DrugMart offer the same 550mg tablets for $469–$491 per 30 tablets, providing up to 75% in monthly savings for uninsured or cash-pay patients.
Commercial Insurance May Reduce Costs to $0 with a Copay Card: Through the Xifaxan Solutions Savings Program, eligible commercially insured patients can pay $0 out of pocket, with a monthly savings cap of $1,150. This program is not available to Medicare or Medicaid patients.
Cheapest Online Pharmacies for Xifaxan (Rifaximin)
Here are the cheapest online pharmacies where you can purchase Xifaxan (Rifaximin) and get it shipped safely, right to your door.
Pharmacy | Prescription Required | Price Per 30 Tablets (Adjusted) | Milligram | Website |
Planet Drugs Direct | Yes | $468.75 | 550mg | |
DrugMart | Yes | $491.31 | 550mg | |
Amazon Pharmacy | Yes | $1,766.43 | 550mg |
Prices as of April 30, 2025. Prices are subject to change based on quantity, milligram, and other details regarding your prescription needs.
U.S. Retail Prices for Xifaxan (Rifaximin)
Retail pharmacy prices remain high for Xifaxan (Rifaximin). Based on recent April 2025 data, the average cost for a 30-day supply at major local pharmacies includes:
Jewel-Osco: $1,582.00
Walgreens: $1,782.00
Walmart: $1,803.00
Target: $1,729.00
Meijer: $1,668.00
Ready to purchase your medication for up to 80% off? Visit Planet Drugs Direct.
How to Save on Xifaxan (Rifaximin)
Here are some ways to save on Xifaxan (Rifaximin):
1. Use the Xifaxan Solutions Savings Card (Commercial Insurance Only)
Eligible patients with commercial insurance can access the Xifaxan Savings Card through Salix Pharmaceuticals, which reduces copays to $0 per fill, up to a maximum savings of $1,150 per month.
Program requirements:
Must be commercially insured
Not valid for patients enrolled in federal or state healthcare programs (Medicare, Medicaid, TRICARE, etc.)
Card must be presented at a participating pharmacy
2. Buy from a CIPA-Certified Online Pharmacy
Uninsured or cash-pay patients can purchase Xifaxan from CIPA-accredited pharmacies at a 50%+ discount. These pharmacies are licensed to export medications and ship directly to the U.S. with a valid prescription.
3. Ask Your Doctor to Submit for Prior Authorization
Xifaxan often requires prior authorization due to its high cost. Your provider may need to demonstrate diagnosis criteria, failed alternatives, or treatment duration to get it covered.
Common Questions About Xifaxan (Rifaximin)
Common questions and answers:
1. Is Xifaxan covered by Medicare?
Yes, but coverage can vary. Medicare Part D plans often cover Xifaxan, but copays may still exceed $500–$1,000 per fill, depending on your plan and phase of coverage.
2. How much would I expect to pay if I have commercial insurance?
If eligible for the Xifaxan Solutions Savings Program, you may pay $0 out of pocket, depending on your plan and pharmacy. Without the card, costs can exceed $1,000–$3,000 per fill.
3. How much would Xifaxan cost without insurance?
Without insurance, a 30-day supply (90 tablets) of Xifaxan 550mg typically costs $5,000–$5,300 at U.S. pharmacies. Ordering through a CIPA-certified pharmacy may reduce your monthly cost to under $500.
Rely on PlanetDrugsDirect.com to Buy Online Xifaxan (Rifaximin)
As a trusted prescription referral service, we offer important benefits whenever you order online. Each of our partner pharmacies and/or government-approved dispensaries is committed to providing the best experience possible of any online prescription referral service on the internet. We offer:
Low prices
Quick turn-around times
Generic and brand-name medications
Unparalleled customer service
Sources
Salix Pharmaceuticals. (2017, December). Xifaxan (rifaximin) tablets, for oral use: Prescribing information. U.S. Food and Drug Administration. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021361s023lbl.pdf
Salix Pharmaceuticals. (n.d.). Xifaxan Copay Savings Program. Retrieved April 30, 2025, from https://xifaxan.copaysavingsprogram.com/
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